Proscillaridin
Medicinal Chemistry
Molecular Weight
530.65
Molecular Formula
C30H42O8
IUPAC Name
14-hydroxy-3beta-(alpha-L-rhamnopyranosyloxy)bufa-4,20,22-trienolide
Pharmacognosy
Biological Source
Drimia maritima (Squill)
Active Constituents
Proscillaridin A
Pharmacology & Synthesis
Mechanism of Action
Inhibits Na+/K+-ATPase pump; bufa-dienolide type cardiac glycoside.
Pharmacokinetics (ADME)
A: Rapid but incomplete oral absorption.
D: Low protein binding.
M: Hepatic (rapid).
E: Biliary and renal (short half-life).
Pharmacodynamics
Positive inotropy; less cumulative toxicity than digoxin due to short half-life.
Synthesis Pathway
Biosynthesized from steroidal precursors.
Safety, Warnings & Interactions
Adverse Effects
Nausea, vomiting, diarrhea, cardiac arrhythmias.
Contraindications
Ventricular fibrillation, hypokalemia.
Drug Interactions
Diuretics, amiodarone.
Pharmaceutics & Compendia
Dosage Forms
Tablets
Official Compendia
BP