Hesperidin
Medicinal Chemistry
Molecular Weight
610.56
Molecular Formula
C28H34O15
IUPAC Name
(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy]-2,3-dihydrochromen-4-one
Pharmacognosy
Biological Source
Citrus sinensis, Citrus aurantium (Sweet/Bitter Orange)
Active Constituents
Hesperidin
Pharmacology & Synthesis
Mechanism of Action
Reduces capillary permeability and possesses potent antioxidant/anti-inflammatory activity.
Pharmacokinetics (ADME)
A: Variable oral absorption (depends on gut flora).
D: Widely distributed.
M: Converted to hesperetin by intestinal bacteria.
E: Renal.
Pharmacodynamics
Improves venous tone, protects blood vessels, decreases inflammation.
Synthesis Pathway
Biosynthesized via the shikimate and polyketide pathways.
Safety, Warnings & Interactions
Adverse Effects
GI discomfort, mild diarrhea.
Contraindications
Bleeding disorders.
Drug Interactions
Antiplatelet drugs (mild additive effect).
Pharmaceutics & Compendia
Dosage Forms
Capsules, Tablets
Official Compendia
BP