Gentiopicroside
Medicinal Chemistry
Molecular Weight
356.32
Molecular Formula
C16H20O9
IUPAC Name
(5R,6S)-5-ethenyl-6-(beta-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one
Pharmacognosy
Biological Source
Gentiana lutea (Yellow Gentian)
Active Constituents
Gentiopicroside, Amarogentin
Pharmacology & Synthesis
Mechanism of Action
Stimulates taste buds in the mouth, triggering reflex increase in saliva and gastric juice secretion.
Pharmacokinetics (ADME)
A: Poorly absorbed.
D: Acts locally in GI tract.
M: GI tract breakdown.
E: Fecal.
Pharmacodynamics
Improves appetite, enhances digestion (sialagogue and orexigenic).
Synthesis Pathway
Biosynthesized via the mevalonate pathway (geraniol precursor).
Safety, Warnings & Interactions
Adverse Effects
Occasional headache, hyperacidity.
Contraindications
Gastric or duodenal ulcers.
Drug Interactions
None significant.
Pharmaceutics & Compendia
Dosage Forms
Tinctures, Extracts
Official Compendia
BP