Diosmin
Medicinal Chemistry
Molecular Weight
608.54
Molecular Formula
C28H32O15
IUPAC Name
7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
Pharmacognosy
Biological Source
Citrus species, Teucrium gnaphalodes (semi-synthetic from Hesperidin)
Active Constituents
Diosmin
Pharmacology & Synthesis
Mechanism of Action
Prolongs the vasoconstrictor effect of noradrenaline on the vein wall, increasing venous tone.
Pharmacokinetics (ADME)
A: Rapid but incomplete.
D: Distributed in peripheral blood vessels.
M: Hepatic and intestinal flora.
E: Renal and fecal.
Pharmacodynamics
Improves venous tone, reduces capillary hyperpermeability, anti-inflammatory.
Synthesis Pathway
Synthesized typically by iodine-assisted oxidation of hesperidin.
Safety, Warnings & Interactions
Adverse Effects
Mild GI upset, headache.
Contraindications
None strictly known; caution in pregnancy.
Drug Interactions
Metronidazole (decreases metabolism of diosmin).
Pharmaceutics & Compendia
Dosage Forms
Tablets, Granules
Official Compendia
BP