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Chemically modified form of a pharmacologically active compound that has to undergo biochemical or chemical transformation before exhibiting its pharmacological effect.
Pharmaceutics Pharmacist Competitive Exams
Q. Chemically modified form of a pharmacologically active compound that has to undergo biochemical or chemical transformation before exhibiting its pharmacological effect.
Ans → prodrug
Explanation →
This question is taken from the test/quiz post: One liners Pharmaceutics| B.Pharmacy| Pharmacy file-7 - attemp/practice
More oneliners in - One liners Pharmaceutics| B.Pharmacy| Pharmacy file-7
Q. Chemically modified form of a pharmacologically active compound that has to undergo biochemical or chemical transformation before exhibiting its pharmacological effect.
Ans → prodrug
Explanation →
Q. Process that differentiates or separates solid particles according to their size using a meshed or perfo- rated device.
Ans → sieving
Explanation →
Q. Different crystalline form of a solvated compound that differ in the identity and/or the stoichiometry of the solvating molecule.
Ans → pseudopolymorph
Explanation →
Q. Method by which powder particles are compressed into a large tablet, called a slug, which is subse- quently dry-screened and compressed into a tablet.
Ans → slugging
Explanation →
Q. Measure of the fraction of a given drug that is absorbed intact into the systemic circulation from a dosage form, relative to a recognized, clinically proven, standard dosage form of that drug.
Ans → relative bioavailability
Explanation →
Q. Dosage form, semi-solid, used for the administration of drugs via the rectal route, for systemic or local effect.
Ans →
Explanation →
Q. Transition of a suspension of solid, usually colloid, particles in a liquid (sol) to an apparent solid, jelly- like material
Ans → sol-gel transition
Explanation →
Q. Usually small, flat, and soft tablets, which are designed to be placed under the tongue to allow direct absorption of the active ingredient through the mucosa for systemic effect.
Ans → sublingual tablets
Explanation →
Q. Additives making a substance soluble or more soluble, especially in water.
Ans → solubilizing agents
Explanation →
Q. Destruction or removal of microorganisms in or about an object, e.g., by steam, chemical agents (alcohol, phenol, ethylene oxide gas), high-velocity electron bombardment, gamma or ultraviolet light radiation or filtration.
Ans → sterilization
Explanation →
Q. Crystalline form of a compound in which one or more solvent molecules are part of the crystal strucure.
Ans → solvate
Explanation →
Q. Condition of being aseptic, or statistically free from living microorganisms and their spores.
Ans → sterility
Explanation →
Q. Process of making dense, spherical pellets by means of special spheronizing or pelletizing equipment.
Ans → spheronization
Explanation →
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Q. The inhibition of the enzyme pancreatic lipase by bile salts is overcome by a protein, namely
Ans → Colipase
Explanation →
Q. Name the painless ulcer that develops at the site of infection in primary syphilis
Ans → hard chancre
Explanation →
Q. Hypercholesterolemia is observed in the disorder(s)
Ans → Hypothyroidism, Diabetes mellitus, Nephrotic syndrome
Explanation →
Q. Which enzymes in glycolysis catalyses an irreversible reaction
Ans → Pyruvate kinase , Phosphofructokinase, Hexokinase
Explanation →
Q. An instrument used to measure the amount of rotation of plane polarized light by a compound, generally prepared in a solution
Ans → polarimeter
Explanation →
Q. Usually small, flat, and soft tablets, which are designed to be placed under the tongue to allow direct absorption of the active ingredient through the mucosa for systemic effect.
Ans → sublingual tablets
Explanation →
Q. The immunoglobulin that can cross the placenta and transfer the mother’s immunity to the developing fetus
Ans → IgG
Explanation →
Q. A type of endocytosis in which extracellular ligands are targeted to specific cells through their binding to specific cell surface receptors
Ans → receptor-mediated endocytosis
Explanation →
Q. Sweet (often colored) dilute alcohol-based, “hydroalcoholic”, liquid used in the compounding of drugs to be taken by mouth in order to improve palatability.
Ans → elixir
Explanation →
Q. Movement of a pathogen from one host to another population through physical contact or through droplet transmission
Ans → horizontal direct transmission
Explanation →
Q. The third stage of acute disease, during which the number of pathogens present in the host is greatest and the signs and symptoms of disease are most severe
Ans → period of illness
Explanation →
Q. Characteristic angle of slope formed with the horizontal by the side of a static conical mound of powder.
Ans → angle of repose
Explanation →
Q. A technique that uses a fluorescence microscope and antibody-specific fluorochromes to determine the presence of specific pathogens in a specimen
Ans → immunofluorescence
Explanation →
Q. The bonds in protein structure that are not broken on denaturation.
Ans → Peptide bonds
Explanation →
Q. The minimum energy which reacting species must possess in order to be able to form an 'activated complex', or 'transition state', before proceeding to the products.
Ans → activation energy
Explanation →
Q. The interval of growth when cells divide exponentially; also known as the exponential growth phase
Ans → log phase
Explanation →
Q. The term given to organic molecules which contain no multiple bonds.
Ans → saturated
Explanation →
Q. DNA-binding proteins found in eukaryotes and archaea that aid in orderly packaging of chromosomal DNA
Ans → histones
Explanation →
Q. The ‘burning feet syndrome’ in man is associated with the deficiency of
Ans → Pantothenic acid
Explanation →
Q. Type of mutation involving the addition of one or more bases into a DNA sequence
Ans → insertion
Explanation →
Q. Trypsin hydrolyses peptide bonds, the carbonyl group of which is contributed by the amino acids
Ans → Arginine and lysine
Explanation →
Q. The glycosaminoglycan that serves as a lubricant and shock absorbant of joints
Ans → Hyaluronic acid
Explanation →
Q. Technique in which antibody or antigen can be concentrated by passing fluids through porous membranes, and target molecules are captured as they pass
Ans → immunofiltration
Explanation →
Q. The mantous test is done to detect the immunity or susceptibility to _____ .
Ans → Tuberculosis
Explanation →
Q. The power of a microscope (or lens) to produce an image that appears larger than the actual specimen, expressed as a factor of the actual size
Ans → magnification
Explanation →
Q. A solid dosage form prepared to a desired shape, usually in large-scale production, by means of high pressure in a punch and die.
Ans → compressed tablet
Explanation →
Q. Examples of two enzymes containing zinc are
Ans → Alcohol dehydrogenase, carbonic anhydrase
Explanation →