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One Liner

binding of Morphine and Naloxone to the Opioid receptors

competitive antagonism
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This question belongs to the set "Revision of Pharmacology, some basic points (one liners)". Click below to read detailed notes and attempt the full quiz.

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  • A Undergoes little first-pass metabolism
  • B Is incompletely absorbed
  • C Is freely water soluble
  • D Is completely absorbed
  • A CYP378A
  • B CYP4B2
  • C CYP3A4
  • D CYP256
Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
  • A Sweat glands
  • B Ciliary muscle
  • C Iris muscles
  • D Splenic capsule
  • A Dapsone
  • B Meperidine
  • C Phenytoin
  • D Chlorpheniramine
Explanation: N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
  • A Carrier is involved
  • B It is against concentration gradient
  • C Energy is required
  • D All of the above
Explanation: Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.
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