General pharmacology Quiz
General pharmacology Quiz
Q1. <div>The following are excreted faster in basic</div><div>urine</div>
because of enhanced disassociation weak acids
are excreted faster in basic (not acidic) urine.
Q2. A good example of chemical antagonism
Chemical antagonism does not involve any
receptors. Protamine is a positively charged
protein at physiological pH and thus
antagonizes the effects of Heparin which is
negatively charged at physiological pH.
Q3. Active transport differs from facilitated transport in following ways, except
Facilitated diffusion differs from active transport
in that it does not require energy source and it
carries the transport in the direction of
electrochemical gradient.
Q4. Acidic drugs mainly bind to plasma
Glycoprotein binds to basic drugs and albumin
binds to many acidic drugs and a small number
of basic drugs.
Q5. _______ is expressed in both the intestinal
epithelium and the kidney.
CYP3A4 is involved in the metabolism of
majority of drugs and is also expressed
extrahepatically. In fact, poor bioavailability of
many drugs is attributed to the drug metabolism
by CYP3A4 in gastrointestinal tract.
Q6. N-oxidation will be involved with the
metabolism of following drugs, except
N-oxidation is involved in the metabolism of
dapsone, meperidine and chloramphenicol.
Metabolism of phenytoin involves oxidative Ndealkylation.
Score: 0 / 6
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