Download PDF – General pharmacology Quiz

General pharmacology Quiz

Q1. The following are excreted faster in basic urine

A) Weak acids

B) Strong acids

C) Weak Bases

D) None of the above

Answer: (A)

because of enhanced disassociation weak acids are excreted faster in basic (not acidic) urine.

Q2. A good example of chemical antagonism

A) Heparin & Protamine

B) Protamine & Zinc

C) Heparin & Prothrombin

D) All the above

Answer: (A)

Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.

Q3. Active transport differs from facilitated transport in following ways, except

A) Carrier is involved

B) It is against concentration gradient

C) Energy is required

D) All of the above

Answer: (A)

Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.

Q4. Acidic drugs mainly bind to plasma

A) Albumin

B) acid glycoprotein

C) Weak acids

D) Heparin & Protamine

Answer: (A)

Glycoprotein binds to basic drugs and albumin binds to many acidic drugs and a small number of basic drugs.

Q5. _______ is expressed in both the intestinal epithelium and the kidney.

A) CYP378A

B) CYP4B2

C) CYP3A4

D) CYP256

Answer: (A)

CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.

Q6. N-oxidation will be involved with the metabolism of following drugs, except

A) Dapsone

B) Meperidine

C) Phenytoin

D) Chlorpheniramine

Answer: (C)

N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.

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