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Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

Pharmacology D. Pharma B. Pharma Bachelor of Pharmacy Diploma in Pharmacy

Q. 5 of Quiz-872 (Que-ID : 1489)

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

  • Undergoes little first-pass metabolism
  • Is incompletely absorbed
  • Is freely water soluble
  • Is completely absorbed

Ans → (b)Is incompletely absorbed

Explanation →

This question is taken from this post → Pharmacology MCQs | Quiz on General Pharmacological Principles - attemp/practice


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Q. 1 of Quiz-872 (Que-ID : 1485)

Compared to subcutaneous injection, the intramus- cular injection of drugs:

  • Is more painful
  • Produces faster response
  • Is unsuitable for depot preparations
  • Carries greater risk of anaphylactic reaction

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Q. 2 of Quiz-872 (Que-ID : 1486)

The majority of drugs cross biological membranes primarily by

  • Passive diffusion
  • Facilitated diffusion
  • Active transport
  • Pinocytosis

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Q. 3 of Quiz-872 (Que-ID : 1487)

Which of the following drugs is most likely to be absorbed from the stomach

  • Hyoscine hydrobromide
  • Morphine sulfate
  • Diclofenac sodium
  • Quinine dihydrochloride

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Q. 4 of Quiz-872 (Que-ID : 1488)

The most important factor governing absorption of a drug from intact skin is

  • Nature of the base used in the formulation
  • Lipid solubility of the drug
  • Molecular weight of the drug
  • Site of application

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Q. 5 of Quiz-872 (Que-ID : 1489)

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

  • Undergoes little first-pass metabolism
  • Is incompletely absorbed
  • Is freely water soluble
  • Is completely absorbed

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Q. 6 of Quiz-872 (Que-ID : 1490)

Marked redistribution is a feature of

  • Highly plasma protein bound drugs
  • Depot preparations
  • Highly lipid soluble drugs
  • Poorly lipid soluble drugs

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Q. 7 of Quiz-872 (Que-ID : 1491)

High plasma protein binding

  • Increases volume of distribution of the drug
  • Generally makes the drug long acting
  • Facilitates glomerular filtration of the drug
  • Minimises drug interactions

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Q. 8 of Quiz-872 (Que-ID : 1492)

Which of the following is a prodrug

  • Enalapril
  • Menapril
  • Thiazine
  • Penicillin

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Q. 9 of Quiz-872 (Que-ID : 1493)

Microsomal enzyme induction can be a cause of

  • Tolerance
  • Physical dependence
  • Psychological dependence
  • Idiosyncrasy

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Q. 10 of Quiz-872 (Que-ID : 1494)

Glomerular filtration of a drug is affected by its

  • Plasma protein binding
  • Lipid solubility
  • Degree of ionization
  • Rate of tubular secretion

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More MCQs In - Pharmacology D. Pharma B. Pharma Bachelor of Pharmacy Diploma in Pharmacy

Directions : For each question, choose a correct option from given four options (A, B, C and D)

Q. 25 of Quiz- (Que-ID : 1239)

Low bioavailability indicates that-

  • drug is poorly absorbed
  • drug is rapidly metabolised
  • drug is not properly relesaed from the formulation
  • all of the above

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Q. 21 of Quiz- (Que-ID : 1114)

The pentothal sodium is a -

  • Local anesthetic
  • Intravenous anesthetic
  • General anesthetic
  • Hypnotic

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Q. 29 of Quiz- (Que-ID : 1095)

which one of these antineoplastic (anticancer) drugs contains platinum?

  • Nitrogen mustard
  • Busulphan
  • Cisplatin
  • Daunorubicin

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Q. 15 of Quiz- (Que-ID : 1824)

Which one of the antibacterial agent is effective against typhoid fever?

  • Chloramphenicol
  • Penicillin
  • Teracycline
  • Sulphathiazole

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Q. 9 of Quiz- (Que-ID : 1516)

The drug which produces vasoconstriction despite being an α adrenergic blocker is

  • Tolazoline
  • Desmopressin
  • Ergotamine
  • Sildenafil

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Q. 9 of Quiz- (Que-ID : 1503)

Pyridostigmine differs from neostigmine in that

  • It produces less muscarinic side effects
  • It is more potent orally
  • It is longer acting
  • It does not have any direct action on NM receptor

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Q. 19 of Quiz- (Que-ID : 692)

Water attack test is is used to identify the alkalinity in:

  • Type I glass
  • Type II glass
  • Type III glass
  • All of these

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Q. 25 of Quiz- (Que-ID : 1118)

Two polypeptide chain in insulin is linked together by -

  • Hydrogen bond
  • Disulphide bond
  • Covalent bond
  • None of the above

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Q. 8 of Quiz- (Que-ID : 1525)

A ______________ section divides the body into right and left portions.

  • sagittal
  • coronal
  • transverse
  • oblique

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Q. 12 of Quiz- (Que-ID : 1362)

Which monosaccharide unit constitutes Milk Sugar?

  • Galactose and glucose
  • 2 galactose units
  • 2 glucose units
  • Fructose and galactose

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Q. 2 of Quiz- (Que-ID : 89)

Which among the given is not suitable for controlled release dosase form

  • Diclofenace
  • Nicotine
  • Carbamazepine
  • Fentanyl

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Q. 25 of Quiz- (Que-ID : 1375)

Xanthine is converted to uric acid in the presence of enzyme-

  • Xanthine oxidase
  • xanthine reductase
  • xanthine transferase
  • xanthine isomerase

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Q. 11 of Quiz- (Que-ID : 1194)

Induction training is meant for -

  • Existing employees
  • New employees
  • Both (a) and (b)
  • None of the above

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Q. 10 of Quiz- (Que-ID : 20)

First line drug for tuberculosis unclude :

  • Isoniazid + ethambutol + pyrizinamide
  • Isoniazid + Rifampin + ethambutol + pyrizinamide
  • Isoniazid + Refampin + ethambutol + para amino salicylic acid
  • Isoniazid + Cycloserine + ethambutol + pyrazinamide

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Q. 32 of Quiz- (Que-ID : 119)

The female insect Coccus cacti is the source of

  • Honey
  • Canthrites
  • Shellac
  • Colchicine

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Q. 18 of Quiz- (Que-ID : 1696)

Ammonium chloride is dried by-

  • Heating to constant weight
  • Keeping in air
  • Drying over desicant
  • All of the above

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Q. 3 of Quiz- (Que-ID : 13)

Thalidomide, effective in insomnia was discarded due to its :

  • Side effect
  • Resistance
  • Idiosyncratic reaction
  • Teratogenic effect

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Q. 30 of Quiz- (Que-ID : 1380)

Menke's disease is related to-

  • deficiency of sulphur
  • deficiency of zinc
  • defect in transport of copper
  • defect in transport of zinc

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Q. 6 of Quiz- (Que-ID : 1456)

In which of the following forms of business organization, registration is compulsory…

  • Partnership firm
  • Sole proprietorship
  • Joint-stock company
  • All of them

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Directions : For each question, choose a correct option from given four options (A, B, C and D)

Q. 9 of Quiz- (Que-ID : 1223)

Hypokalaemia side effect of diuretics can be countered by-

  • Common salt
  • Potassium Chloride
  • Ascorbic acid
  • Any of the above

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Q. 25 of Quiz- (Que-ID : 1059)

The deposition of sodium urate crystals in joints leads to disease -

  • Arthritis
  • Inflammation
  • Gout
  • Calculi

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Q. 16 of Quiz- (Que-ID : 1366)

Multiple forms of same enzymes are called-

  • Coenzyme
  • Apoenzymes
  • Isoenzymes
  • Haloenzymes

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Q. 49 of Quiz- (Que-ID : 136)

Fifth edition of I.P. was published in the year

  • 1985
  • 1996
  • 2007
  • 2015

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Q. 21 of Quiz- (Que-ID : 1204)

A budget is a -

  • Financial statement
  • Quantitative statement
  • A report only
  • Any of the above

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Q. 10 of Quiz- (Que-ID : 1547)

"oculus sinister" is used to indiacate

  • right eye
  • left eye
  • right ear
  • left ear

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Q. 18 of Quiz- (Que-ID : 1278)

The valuable reference material which helps medical and paramedical staff in evaluation is-

  • administrative record
  • medical record
  • hospital formulary
  • none of these

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Q. 12 of Quiz- (Que-ID : 1105)

Which is the non acidic anti-inflammatory agent?

  • Oxyphenbutazone
  • Ibuprofen
  • Piroxicam
  • Nabumetone

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Q. 19 of Quiz- (Que-ID : 1328)

The layout of drug store depends upon-

  • Pharmacist/proprietor
  • Rules specified in shedule N
  • Availability of space
  • All of the above

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Q. 6 of Quiz- (Que-ID : 1815)

Phenytoin act as anti-epilectic drug by-

  • inhibiting the enzyme
  • blocking the receptor
  • acting on cell membrane
  • non-specific drug action

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Q. 28 of Quiz- (Que-ID : 1181)

Which is not a mineral hydrocolloid?

  • Veegum
  • Colloidal silica
  • Colloidal alumina
  • Tragacanth

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Q. 19 of Quiz- (Que-ID : 1053)

Sarcolemma is a covering of 

  • Nerve fibre
  • Muscle fibre
  • Collagen fibre
  • Cartilage

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Q. 21 of Quiz- (Que-ID : 1174)

In situ salt formation is a technique used in drug therapy to overcome -

  • Lack of solubility of salt
  • Poor absorption
  • Chemical instability
  • Complexation problems

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Q. 8 of Quiz- (Que-ID : 1565)

Simple syrup is a saturated solution of…

  • Fructose
  • Mannose
  • Glucose
  • Sucrose

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Q. 1 of Quiz- (Que-ID : 1830)

Vginal sponge, means of family planning belongs to-

  • Physical method
  • Chemical method
  • Hormonal method
  • none of the these

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Q. 29 of Quiz- (Que-ID : 1122)

Aminophylline is salt of ethylenediamine with -

  • Theophylline
  • Caffeine
  • Theobromine
  • None of the above

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Q. 4 of Quiz- (Que-ID : 1354)

one example of glycoside is-

  • Cholesterol
  • Sphingomyelin
  • Lecithin
  • Gangliosides

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Q. 26 of Quiz- (Que-ID : 1119)

Acetazolamide, carbonic anhydrase inhibitor, is used in

  • Glaucoma
  • Hypertension
  • Bacterial infection
  • None of the above

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Q. 22 of Quiz- (Que-ID : 3922)

Appropriate percentage of sulphur in protein is the range of

  • 0-4%
  • 4-8%
  • 8-12%
  • 12-16%

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Q. 17 of Quiz- (Que-ID : 690)

Slugging is related to

  • Wet granulation
  • Mixing
  • Dry granulation
  • Filling of the die

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Q. 22 of Quiz- (Que-ID : 1700)

Which one of these is a major cation in intracellular fluid?

  • Potassium
  • Sodium
  • magnesium
  • calcium

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Q. 18 of Quiz- (Que-ID : 1327)

Coding of items helps in-

  • Handling of store items
  • Standardization of drug
  • Reduction of items
  • All of the above

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