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Which of the following metabolite of cyclophosphamide is responsible for its anti-tumor actitivity?
Pharmacy Pharmacology D. Pharma B. Pharma
Q. 16 of Quiz-66 (Que-ID : 103)
Which of the following metabolite of cyclophosphamide is responsible for its anti-tumor actitivity?
- Phosphoramide mustard
- Acrolein
- Aldophosphamide
- 4-hydroxy cyclophosphamide
Ans → (a)Phosphoramide mustard
Explanation →
This question is taken from this post → Online Practice Test for Pharmacy exams, previous Year questions - attemp/practice
More MCQs in - Online Practice Test for Pharmacy exams, previous Year questions
Q. 1 of Quiz-66 (Que-ID : 88)
Opthalmic solutions are not evaluated for:
- Sterility test
- Active ingredient
- Clarity test
- Pyrogen test
Q. 2 of Quiz-66 (Que-ID : 89)
Which among the given is not suitable for controlled release dosase form
- Diclofenace
- Nicotine
- Carbamazepine
- Fentanyl
Q. 3 of Quiz-66 (Que-ID : 90)
Kries test is related to
- Skin sensitivity studies
- Identification test of resin
- Rancidity index
- Identification test of aloin
Q. 4 of Quiz-66 (Que-ID : 91)
Isoniazid causes hapatotoxicity due to
- Its metabolite acetylhydrazine
- Accumulation of isoniazid in hepatic cells
- Its metabolite acetylisoniazid
- Deficience of pyrifoxine caused by prolonged isoniazid theory
Q. 5 of Quiz-66 (Que-ID : 92)
Which one of the following drug's tablet should be stored in the closely tight container to prevent loss of potency?
- Phenytoin
- Propranolol
- Nitroglycerine
- All of these
Q. 6 of Quiz-66 (Que-ID : 93)
Metabolite of chlordiazepoxide is
- Nordiazepam
- Oxazepam
- Demoxipam
- All of these
Q. 7 of Quiz-66 (Que-ID : 94)
Lemon Grass oil is obtained by steam distilation of the
- Fresh leaves of Eucalyptus globulus
- Fresh flowering tops of the menths piperata
- Leaves of aerial parts of the cymopogon citratus
- Pericarp of the ripe or nearly ripe fruits of citrus limonis
Q. 8 of Quiz-66 (Que-ID : 95)
Azaspirodecandione agents are primarily used in the treatment of
- Obsessive-compulsive disorders
- Schizophrenia
- Anxiety
- Mania
Q. 9 of Quiz-66 (Que-ID : 96)
Praracetamol is a derivative of:
- p-amino phenol
- Aryl acetic acid
- Aryl propionic acid
- Anthranilic acid
Q. 10 of Quiz-66 (Que-ID : 97)
Efficiency of ball mill depends on
- Rotational speed
- Density of balls
- Volume occupied by the balls
- All of these
Q. 11 of Quiz-66 (Que-ID : 98)
Which of the following properties of a drug is affected by micronisation
- Flow properties
- Chemical stability
- Therapeutic effectiveness
- All of these
Q. 12 of Quiz-66 (Que-ID : 99)
The phosphate antiviral agent is
- Ribavirin
- Didanosine
- Ganciclovir
- Foscarnet
Q. 13 of Quiz-66 (Que-ID : 100)
side effect of drugs is arise due to its intraction to cellular molucules other than the target. these effect can be minimized by their:
- specificity
- Solubility
- Affinity
- Hydrophobicity
Q. 14 of Quiz-66 (Que-ID : 101)
Which statement is not correct about levodopa?
- In perkinsonism, phenothiazines reduce its efficacy
- It is a prodrug
- Pyridoxine reduces effect of levodopa in parkinsonism.
- Domperidone blocks levodopa induced emesis and its therapeutic potential
Q. 15 of Quiz-66 (Que-ID : 102)
Most widely used film former in nail lacquer is
- Ethyle cellulose
- cellulose acetate
- cellulose nitrate
- cellulose acetobutyrate
Q. 16 of Quiz-66 (Que-ID : 103)
Which of the following metabolite of cyclophosphamide is responsible for its anti-tumor actitivity?
- Phosphoramide mustard
- Acrolein
- Aldophosphamide
- 4-hydroxy cyclophosphamide
Q. 18 of Quiz-66 (Que-ID : 105)
Food poisoning is caused by :
- Clostridium tetani
- Clostridium welchi
- Clostridium botulinium
- Clostridium septicum
Q. 19 of Quiz-66 (Que-ID : 106)
Which animal is used for studying insulin preparations?
- Horse
- Pigeon
- Rabbit
- Chicken
Q. 20 of Quiz-66 (Que-ID : 107)
Geiger muller counter is used in :
- UV specroscopy
- Ionisation methods
- IR spectroscopy
- NMR spectroscopy
Q. 21 of Quiz-66 (Que-ID : 108)
Antipsychotic drug-induced parkinsonism is treated by
- Trihexyphenidyl
- Levodopa
- Selegiline
- Amantadine
Q. 22 of Quiz-66 (Que-ID : 109)
As per drug and cosmetic act 1940 phenobarbitone sodium belongs to
- Schedule L
- Shedule X
- Shedule R
- Shedule O
Q. 23 of Quiz-66 (Que-ID : 110)
Menthol is the main constituent of the volatile oil of
- Pinus leaf
- Peppermint leaf
- Clove buds
- Rose marry
Q. 24 of Quiz-66 (Que-ID : 111)
The nitrogen in ephedrine is present as a
- Primary amine
- Secondary amines
- Tertiary amines
- Quarternary amines
Q. 26 of Quiz-66 (Que-ID : 113)
Sterilisation of packed food such as milk and meat products can be done by
- Gas
- Moist heat
- Radiation
- Dry heat
Q. 27 of Quiz-66 (Que-ID : 114)
Chlorophyll test is positive in
- Male fern
- Clove
- Rhubarb
- Pale catechu
Q. 28 of Quiz-66 (Que-ID : 115)
Removal of para-nitro group of chloramphenicol may
- Increases the toxicity
- Decreases bitterness
- Decreses potency
- Increases water solubility
Q. 29 of Quiz-66 (Que-ID : 116)
A process of sepration of molecules through the use of semi-permeable membrane is known as
- Osmosis
- Dialysis
- Seiving
- Diffusion
Q. 30 of Quiz-66 (Que-ID : 117)
Which one of the following is the initial step in the absorption of the drug from a tablet
- Deaggregation
- Diffusion
- Disintegration
- Dissolutuin
Q. 32 of Quiz-66 (Que-ID : 119)
The female insect Coccus cacti is the source of
- Honey
- Canthrites
- Shellac
- Colchicine
Q. 33 of Quiz-66 (Que-ID : 120)
Tragacanth in water is associated with
- Plastic flow
- Pseudoplatic flow
- Dialatant flow
- None of these
Q. 34 of Quiz-66 (Que-ID : 121)
Antioxidants are added in lipstics to
- Impart pleasant ordour
- Staining of lips
- Dissolving insoluble Pigments and dyes
- Prevent rancidity
Q. 35 of Quiz-66 (Que-ID : 122)
Borntrager test is used to identification of
- Senna
- Squill
- Cinchona
- Digitalis
Q. 36 of Quiz-66 (Que-ID : 123)
Plasma protiens act as
- Reserve protiens
- Immunoglobulins
- Buffers
- All of these
Q. 37 of Quiz-66 (Que-ID : 124)
Ketone bodies are synthesised from the fatty acid oxidisation products by which of the following organ
- Brain
- Liver
- Skeletal muscle
- Kidney
Q. 38 of Quiz-66 (Que-ID : 125)
An example of protien denaturation is
- Dissolving sugar in water
- Metabolism of meat
- Heating milk
- Heating egg
Q. 39 of Quiz-66 (Que-ID : 126)
An enzyme catalysed the conversion of alddose sugar to ketose sugar would be classified as
- Isomerases
- Transferases
- Hydrolysases
- Oxydoreductases
Q. 40 of Quiz-66 (Que-ID : 127)
The constituent of essential oil is
- Polyterpenoid
- Tetraterpenoid
- mono and sesquiterpenoid
- Triterpenoid
Q. 41 of Quiz-66 (Que-ID : 128)
Which of the given combination has an intraction, beneficial for routine clinical use?
- Hydralazine and atenolol
- Metochlopramide and levodopa
- Quinidine and digoxine
- Furosemide and lithium carbonate
Q. 42 of Quiz-66 (Que-ID : 129)
Hyperuricemia is associated with the the abnormal metabolism of
- Purine
- Thiamine
- Riboflavin
- Pyrimidine
Q. 43 of Quiz-66 (Que-ID : 130)
Active immunity is induced by
- Placental transfer of antibodies
- Infection
- Injection of gamma-globulins
- Injection of antibodies
Q. 44 of Quiz-66 (Que-ID : 131)
HIV infection can be clinical controlled with
- Ribavirin
- Ganciclovir
- Stavudine
- Acyclovir
Q. 45 of Quiz-66 (Que-ID : 132)
An anti-arrythmic drug that is also used to control seizures is
- Lidocain
- Disipyramide
- Phenytoin
- Amiodarone
Q. 46 of Quiz-66 (Que-ID : 133)
Drug of choice for thyroid storm is
- Carbimazole
- Radioactive iodine
- Propyl thiouracil
- Centimizone
Q. 47 of Quiz-66 (Que-ID : 134)
The cellular organells called 'suiside bags' are
- Lysosomes
- Nucleolus
- Ribosomes
- Golgi's bodies
Q. 48 of Quiz-66 (Que-ID : 135)
The drug included in 'dope test' for athletes is
- Propranolol
- Prazocine
- Dexamphetamine
- Diazepam
Q. 50 of Quiz-66 (Que-ID : 137)
List of minimum equipements required for efficient running of pharmacy is given in shedule
- M
- N
- A
- R
More MCQs In - Pharmacy Pharmacology D. Pharma B. Pharma
Q. 20 of Quiz- (Que-ID : 107)
Geiger muller counter is used in :
- UV specroscopy
- Ionisation methods
- IR spectroscopy
- NMR spectroscopy
Q. 57 of Quiz- (Que-ID : 234)
Which one of these is an anabolic steroid?
- Testosterone propionate
- Fluxymesterone
- Stanozolol
- None of these
Directions : For each question, choose a correct option from given four options (A, B, C and D)
Q. 9 of Quiz- (Que-ID : 1223)Hypokalaemia side effect of diuretics can be countered by-
- Common salt
- Potassium Chloride
- Ascorbic acid
- Any of the above
Q. 29 of Quiz- (Que-ID : 116)
A process of sepration of molecules through the use of semi-permeable membrane is known as
- Osmosis
- Dialysis
- Seiving
- Diffusion
Q. 30 of Quiz- (Que-ID : 1096)
The organophosphate poisoning is treated by
- Neostigmine
- Physostigmine
- Pralidoxime
- Pyridostigmine
Q. 16 of Quiz- (Que-ID : 1366)
Multiple forms of same enzymes are called-
- Coenzyme
- Apoenzymes
- Isoenzymes
- Haloenzymes
Q. 3 of Quiz- (Que-ID : 1624)
Which of the following is physical agent of cell injury?
- Dil. HCl
- Hypoxia
- Viruses
- Hot Surface
Q. 29 of Quiz- (Que-ID : 1122)
Aminophylline is salt of ethylenediamine with -
- Theophylline
- Caffeine
- Theobromine
- None of the above
Q. 20 of Quiz- (Que-ID : 1280)
An opthalmic solution is sterilized by-
- Autoclaving
- Sterilization by filtration
- Gaseous sterilization
- Dry heat sterilization
Q. 30 of Quiz- (Que-ID : 1290)
Allopurinol when administered with mercaptopurine, increases the action of mercaptopurine by-
- Inhibiting the enzyme - Xanthine oxidase
- decreasing its absorption
- displacing from proteine binding site
- none of these
Q. 2 of Quiz- (Que-ID : 1509)
Select the β-adrenergic blocker that has additional β1blocking, vasodilator and antioxidant properties
- Celiprolol
- Metoprolol
- Carvedilol
- Acebutolol
Q. 9 of Quiz- (Que-ID : 1192)
Patent, copyright, trademarks comes under which type of assets?
- Current assets
- Intangible assets
- Tangible assets
- Miscellaneous assets
Q. 7 of Quiz- (Que-ID : 1514)
Which of the following is a selective α1A receptor bloc- ker that affords symptomatic relief in benign prostatic hypertrophy without producing significant fall in blood pressure
- Doxazosin
- Alprostadil
- Tamsulosin
- Yohimbine
Q. 5 of Quiz- (Que-ID : 3905)
Normal urine is
- Neutral
- Highly acidic
- Slightly alkaline
- Slightly acidic
Q. 28 of Quiz- (Que-ID : 1288)
if a petient who has been stabilized on aspirin, starts taking phenylbultazone, then the free salicylate concentration will
- Increase
- decrease
- remains unaffected
- none of these
Q. 18 of Quiz- (Que-ID : 635)
Which of the following are prohibited to be imported?
- Toilet preparation
- Misbranded drugs
- Unani drugs
- None of the above
Q. 72 of Quiz- (Que-ID : 249)
The shells of soft gellatin capsules may be made ellastic or plastic like by the addition of:
- Sorbitol
- Cmc
- Water
- Alcohol
Q. 3 of Quiz- (Que-ID : 3903)
Alkaline phosphate level is increased in
- Ricket
- Leukemia
- Cardial infection
- Pancreatic deficiency
Q. 17 of Quiz- (Que-ID : 1826)
Pharmaclogical action of morphine is-
- CNS stimulant
- Vasoconstriction
- Increase in blood pressure
- Release of histamine
Q. 5 of Quiz- (Que-ID : 1098)
Pseudoephedrine differs from ephedrine in -
- Chemical structure
- Isomerism
- Activity
- Activity and isomerism
Q. 19 of Quiz- (Que-ID : 1085)
Hydrocortisone differ from cortisone in possessing -
- Basic nucleus
- Double bond
- Hydroxy group in place of keto group at C-11
- None of the above
Q. 3 of Quiz- (Que-ID : 90)
Kries test is related to
- Skin sensitivity studies
- Identification test of resin
- Rancidity index
- Identification test of aloin
Directions : For each question, choose a correct option from given four options (A, B, C and D)
Q. 8 of Quiz- (Que-ID : 1222)The drug contraindicated in active tuberculosis?
- INH
- PABA
- PAS
- Hdrocortisone
Q. 23 of Quiz- (Que-ID : 1146)
Hydroxymethyl cellulose is added in eye drops to -
- Enhance viscosity
- Maintain pH
- Provide isotonicity
- None of the above
Q. 7 of Quiz- (Que-ID : 1491)
High plasma protein binding
- Increases volume of distribution of the drug
- Generally makes the drug long acting
- Facilitates glomerular filtration of the drug
- Minimises drug interactions
Q. 9 of Quiz- (Que-ID : 1476)
Substances which anesthetize the restricted area without making subject unconscious…
- Local anaesthetic
- Antiemetics
- General anaesthetic
- Analgesics
Q. 24 of Quiz- (Que-ID : 1090)
Which one of these drugs is used as an opthalmic diagnostic agent?
- Fluorescein sodium
- Congo red
- Methelene blue
- Indigo carmine
Q. 16 of Quiz- (Que-ID : 1169)
Dextrose injection is sterilised by
- Hot air oven
- Autoclave
- Tyndallization
- Pasteurization
Q. 10 of Quiz- (Que-ID : 1163)
Pharmagel A is obtained by :
- Acid hydrolysis
- Enzymatic hydrolysis
- Basic hydrolysis
- None of the above
Q. 41 of Quiz- (Que-ID : 128)
Which of the given combination has an intraction, beneficial for routine clinical use?
- Hydralazine and atenolol
- Metochlopramide and levodopa
- Quinidine and digoxine
- Furosemide and lithium carbonate
Q. 7 of Quiz- (Que-ID : 680)
Which filter is used for bacterial filtration?
- Filter paper
- Sintered glass filter
- Membrane filter
- none of these
Q. 22 of Quiz- (Que-ID : 3922)
Appropriate percentage of sulphur in protein is the range of
- 0-4%
- 4-8%
- 8-12%
- 12-16%
Q. 19 of Quiz- (Que-ID : 106)
Which animal is used for studying insulin preparations?
- Horse
- Pigeon
- Rabbit
- Chicken
Q. 63 of Quiz- (Que-ID : 240)
Diltiazem is a:
- Benzodiezipine derivative
- Benzothiazepine derivative
- Thiazolidine derivative
- None of these
Q. 10 of Quiz- (Que-ID : 1614)
In the EMP pathway, the steps involved are ……
- Energy generation phase
- Energy investment phase
- Splitting phase
- All of them
Q. 12 of Quiz- (Que-ID : 629)
Minimum requirements for grant of licence to procure blood components from whole human blood is give in which schedule?
- F1
- F(i)
- F(ii)
- F2
Q. 4 of Quiz- (Que-ID : 1571)
What is a “trochanter”?
- projection that forms part of an articulation
- part of a femur
- groove in which lies a tendon
- a feature of the pelvis
Q. 1 of Quiz- (Que-ID : 425)
Origin of Bramaputra River
- Yamunotri Glacier, Uttarakhand
- Angsi Glacier in the Himalayas in Tibet,
- Ladakh
- Srinagar
Q. 79 of Quiz- (Que-ID : 256)
The most essential fatty acid is:
- Linoleic acid
- Linolenic acid
- Arachidonic acid
- Stearic acid
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