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One Liner

The percent of dose entering the systemic circulation after administration of a given dosage form.

Bioavailability
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This question belongs to the set "Pharmacology Chapter 1 Revision: Key One-Liner Questions for Pharmacist Exams". Click below to read detailed notes and attempt the full quiz.

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  • A Colon
  • B Gastric fundus
  • C Bladder trigone
  • D Major bronchi
  • A Dapsone
  • B Meperidine
  • C Phenytoin
  • D Chlorpheniramine
Explanation: N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
  • A CYP378A
  • B CYP4B2
  • C CYP3A4
  • D CYP256
Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
  • A Carrier is involved
  • B It is against concentration gradient
  • C Energy is required
  • D All of the above
Explanation: Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.
  • A Neuromuscular junction
  • B Postganglionic parasympathetic
  • C Adrenal medulla
  • D Autonomic ganglia
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