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The joint effect of two or more drugs such that the combined effect is less than the sum of the effects produced by each agent separately.

Antagonism
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This question belongs to the set "Pharmacology Chapter 1 Revision: Key One-Liner Questions for Pharmacist Exams". Click below to read detailed notes and attempt the full quiz.

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  • A It produces less muscarinic side effects
  • B It is more potent orally
  • C It is longer acting
  • D It does not have any direct action on NM receptor
  • A Heparin & Protamine
  • B Protamine & Zinc
  • C Heparin & Prothrombin
  • D All the above
Explanation: Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.
  • A Nature of the base used in the formulation
  • B Lipid solubility of the drug
  • C Molecular weight of the drug
  • D Site of application
  • A Weak acids
  • B Strong acids
  • C Weak Bases
  • D None of the above
Explanation: because of enhanced disassociation weak acids are excreted faster in basic (not acidic) urine.
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