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_______ is expressed in both the intestinal
epithelium and the kidney.
Question:
_______ is expressed in both the intestinal epithelium and the kidney.
Choose the correct answer:
- A. CYP378A ✅ Correct
- B. CYP4B2
- C. CYP3A4
- D. CYP256
Explanation:
CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
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Related MCQs
The following are excreted faster in basicurine
Explanation:
because of enhanced disassociation weak acids
are excreted faster in basic (not acidic) urine.
A good example of chemical antagonism
Explanation:
Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.
Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.
Active transport differs from facilitated transport in following ways, except
Explanation:
Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.
Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.
Acidic drugs mainly bind to plasma
Explanation:
Glycoprotein binds to basic drugs and albumin binds to many acidic drugs and a small number of basic drugs.
Glycoprotein binds to basic drugs and albumin binds to many acidic drugs and a small number of basic drugs.
N-oxidation will be involved with the
metabolism of following drugs, except
Explanation:
N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
Compared to subcutaneous injection, the intramus- cular injection of drugs:
The majority of drugs cross biological membranes primarily by
Which of the following drugs is most likely to be absorbed from the stomach
The most important factor governing absorption of a drug from intact skin is
Bioavailability differences among oral formulations of a drug are most likely to occur if the drug
Marked redistribution is a feature of
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