Download PDF – RRB Pharmacist PYQ Special Mock Test: From Official PYPs

RRB Pharmacist PYQ Special Mock Test: From Official PYPs

Q1. The volume of blood pumped out by each ventricle of the heart per minute is clinically defined as:

A) Stroke Volume

B) Tidal Volume

C) Cardiac Output

D) End-Diastolic Volume

Answer: (C)

Cardiac output represents the total volume of blood ejected by each ventricle into the systemic or pulmonary circulation per minute. It is calculated mathematically as Cardiac Output = Stroke Volume (approx. 70 mL) * Heart Rate (approx. 72 bpm), which averages roughly 5 Liters per minute in a resting healthy adult.

Q2. Which of the following cellular components in the nervous system is directly responsible for generating the protective myelin sheath around peripheral neuronal axons?

A) Astrocytes

B) Schwann cells

C) Microglia

D) Oligodendrocytes

Answer: (B)

In the Peripheral Nervous System (PNS), Schwann cells envelope peripheral neuronal axons to form the insulating, lipid-rich myelin sheath that enables rapid saltatory nerve conduction. In contrast, Oligodendrocytes perform this same myelination function exclusively within the Central Nervous System (CNS).

Q3. A patient in the trauma unit sustains a blunt injury to the spinal cord. At which vertebral level does the spinal cord typically terminate as the conus medullaris in a normal adult?

A) At the level of L1 to L2 vertebrae

B) At the level of T10 to T11 vertebrae

C) At the level of L4 to L5 vertebrae

D) At the lower border of S2 vertebra

Answer: (A)

In adults, the spinal cord terminates anatomically at the conus medullaris around the intervertebral level of L1 to L2. The subarachnoid space extends down to the lower border of S2, which provides a safe anatomical site for performing lumbar punctures (spinal taps) between the L3-L4 or L4-L5 intervertebral spaces.

Q4. According to the British and Indian Pharmacopoeias, the term 'Very Slightly Soluble' refers to a substance requiring how many parts of solvent to dissolve 1 part of solute?

A) From 100 to 1000 parts

B) From 1000 to 10000 parts

C) More than 10000 parts

D) From 30 to 100 parts

Answer: (B)

According to compendial solubility criteria: Freely soluble requires 1 to 10 parts; Soluble requires 10 to 30 parts; Sparingly soluble requires 30 to 100 parts; Slightly soluble requires 100 to 1000 parts; Very slightly soluble requires 1,000 to 10,000 parts; and Practically insoluble requires more than 10,000 parts of solvent per 1 part of solute.

Q5. In the formulation of pharmaceutical suspensions, the primary driving force responsible for the undesirable growth of large crystals at the expense of smaller particles upon storage is termed:

A) Brownian movement

B) Ostwald ripening

C) Phase inversion

D) Thixotropic hysteresis

Answer: (B)

Ostwald ripening is a physical phenomenon observed in suspensions where smaller particles have higher surface energy and higher solubility than larger particles. Over time, small particles dissolve into the surrounding medium and recrystallize onto the surfaces of larger particles, resulting in an upward shift in average particle size and compromising physical stability.

Q6. Match List-I (Dosage Form / Packaging) with List-II (Specific Quality Control Apparatus):
List-I
A. Tablet Friability
B. Tablet Disintegration
C. Suppository Hardness
D. Parenteral Particulate Matter
List-II
1. Basket-rack assembly in 37 degrees water bath
2. Roche drum revolving at 25 rpm
3. Light obscuration / microscopic particle counter
4. Krowczynski fracture penetration tester

A) A-2, B-1, C-4, D-3

B) A-1, B-2, C-3, D-4

C) A-2, B-4, C-1, D-3

D) A-3, B-1, C-4, D-2

Answer: (A)

Roche Friabilator (A-2) drops tablets across 100 revolutions to measure weight loss. Disintegration test (B-1) uses a guided basket-rack assembly agitated at 37°C. Suppository breaking strength (C-4) is evaluated using penetration apparatuses like the Krowczynski tester. Parenteral micro-particulates (D-3) are quantified via light obscuration counters.

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