Download PDF – RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP

RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP

Q1. What is documented assurance that a process consistently produces products meeting specifications called?

A) Equipment Qualification (IQ/OQ/PQ)

B) Instrument Calibration

C) Process Validation

D) Vendor Auditing

Q1. विशिष्टताओं (Specifications) के अनुरूप उत्पाद लगातार बनाने की प्रलेखित साक्ष्य (documented assurance) को क्या कहते हैं?

A) उपकरण योग्यता (Equipment Qualification)

B) उपकरण अंशांकन (Instrument Calibration)

C) प्रक्रिया सत्यापन (Process Validation)

D) वेंडर ऑडिटिंग

Answer: (C)

Process Validation is documented evidence providing a high degree of assurance that a process can consistently produce a product meeting predetermined specifications and quality attributes. Validation approaches and batch requirements depend on applicable regulatory guidance; three consecutive batches are not a universal rule.

प्रक्रिया सत्यापन (Process validation) प्रलेखित साक्ष्य (documented evidence) देता है कि प्रक्रिया लगातार पूर्व-निर्धारित गुणवत्ता विशिष्टताओं (predetermined quality specifications) को पूरा करने वाला उत्पाद बना सकती है।

Q2. Which cuvette material is required for UV absorbance below 320 nm?

A) Standard flint optical glass

B) Transparent polystyrene plastic

C) Fused quartz or synthetic silica

D) Pyrex borosilicate glass

Q2. 320 nm से कम UV अवशोषण (absorbance) के लिए क्युवेट (cuvette) किस पदार्थ का होना चाहिए?

A) सामान्य फ्लिंट कांच (flint glass)

B) पारदर्शी पॉलीस्टाइरीन प्लास्टिक

C) फ्यूज्ड क्वार्ट्ज (Fused quartz) या सिंथेटिक सिलिका

D) पायरेक्स बोरोसिलिकेट कांच (Pyrex borosilicate glass)

Answer: (C)

Standard optical flint glass and regular plastic cuvettes strongly absorb electromagnetic radiation in the ultraviolet region (below 320–350 nm) due to silicate and polymer backbones, rendering them opaque to UV light. Therefore, spectrophotometric measurements across the UV wavelength range (200 nm to 380 nm) strictly require sample cuvettes fabricated from high-purity fused quartz or synthetic silica, which are optically transparent down to 190 nm.

कांच और सामान्य प्लास्टिक UV को अवशोषित (absorb) करते हैं। फ्यूज्ड क्वार्ट्ज/सिलिका लगभग 190 nm तक UV-पारदर्शी (UV-transparent) होता है, इसलिए UV मापन के लिए उपयुक्त है।

Q3. Which chromatography separates molecules by hydrodynamic size/volume?

A) Affinity chromatography

B) Hydrophobic interaction chromatography

C) Gel filtration / Size-Exclusion Chromatography (SEC)

D) Chiral ligand-exchange chromatography

Q3. कौन-सी क्रोमैटोग्राफी अणुओं को हाइड्रोडायनामिक आकार/आयतन (hydrodynamic size/volume) के आधार पर अलग करती है?

A) एफिनिटी क्रोमैटोग्राफी

B) हाइड्रोफोबिक इंटरेक्शन क्रोमैटोग्राफी

C) जेल निस्पंदन / साइज-एक्सक्लूज़न क्रोमैटोग्राफी (SEC)

D) काइरल लिगैंड-एक्सचेंज क्रोमैटोग्राफी

Answer: (C)

Size-Exclusion Chromatography (SEC)—termed gel filtration when using aqueous mobile phases and gel permeation when using organic solvents—separates biomolecules purely according to molecular size and hydrodynamic volume. The column is packed with porous polymer beads (e.g., cross-linked dextran, agarose, polyacrylamide). Small molecules penetrate the internal pores and elute late, whereas large molecules exceeding the pore exclusion limit bypass the pores and elute first in the void volume.

SEC/जेल निस्पंदन अणुओं को हाइड्रोडायनामिक आकार के आधार पर अलग करती है। बड़े अणु छिद्रों (pores) में कम प्रवेश करके पहले निक्षालित (elute) होते हैं; छोटे देर से।

Q4. In TLC, what is the ratio of solute-spot distance to solvent-front distance called?

A) Retention factor (Rf value)

B) Resolution factor (Rs)

C) Capacity factor (k')

D) Selectivity coefficient (alpha)

Q4. TLC में विलेय स्पॉट (solute-spot) की दूरी और विलायक अग्र (solvent-front) की दूरी के अनुपात को क्या कहते हैं?

A) रिटेंशन फैक्टर / प्रतिधारण कारक (Rf)

B) रेजोल्यूशन फैक्टर (Rs)

C) कैपेसिटी फैक्टर (k′)

D) सेलेक्टिविटी गुणांक (α)

Answer: (A)

In TLC, Rf = distance traveled by the center of the solute spot / distance traveled by the solvent front. Rf is dimensionless and generally lies between 0 and 1 under ordinary conditions; values depend on the stationary phase, mobile phase, and experimental conditions.

Rf = विलेय स्पॉट द्वारा तय दूरी ÷ विलायक अग्र द्वारा तय दूरी। यह आयामहीन (dimensionless) है और सामान्यतः 0 से 1 के बीच होता है।

Q5. Which primary standard is used to standardize HCl volumetric solution?

A) Anhydrous Sodium Carbonate (Na2CO3)

B) Potassium Bromate

C) Sodium Thiosulfate

D) Ferrous Ammonium Sulfate (Mohr's salt)

Q5. HCl आयतनी विलयन (volumetric solution) को मानकीकृत करने के लिए कौन-सा प्राथमिक मानक प्रयोग होता है?

A) निर्जल सोडियम कार्बोनेट (Na₂CO₃)

B) पोटैशियम ब्रोमेट

C) सोडियम थायोसल्फेट

D) फेरस अमोनियम सल्फेट (मोहर लवण)

Answer: (A)

Anhydrous sodium carbonate (Na2CO3) is the official primary standard used for standardizing hydrochloric acid (HCl) or sulfuric acid (H2SO4) volumetric solutions. It can be prepared in exceptional chemical purity by heating pure sodium bicarbonate at 270°C to constant weight. It neutralizes strong mineral acids in a 1:2 molar ratio using methyl orange as the visual indicator.

निर्जल (Anhydrous) Na₂CO₃ प्राथमिक मानक से HCl को मानकीकृत (standardize) किया जाता है; यह प्रबल अम्ल (strong acid) के साथ 1:2 मोलर अनुपात (molar ratio) में प्रतिक्रिया करता है।

Q6. Which argentometric method gives a brick-red Ag₂CrO₄ endpoint in neutral solution?

A) Volhard's indirect back-titration method

B) Fajans adsorption indicator method

C) Potentiometric fluoride titration

D) Mohr's direct argentometric method

Q6. कौन-सी अर्जेंटोमेट्रिक विधि (argentometric method) उदासीन विलयन (neutral solution) में ईंट-लाल (brick-red) Ag₂CrO₄ समापन बिंदु (endpoint) देती है?

A) वोल्हार्ड की अप्रत्यक्ष पश्च-अनुमापन (indirect back-titration)

B) फ़जन्स (Fajans) अधिशोषण संकेतक (adsorption indicator) विधि

C) पोटेंशियोमेट्रिक फ्लोराइड अनुमापन

D) मोहर (Mohr) की प्रत्यक्ष अर्जेंटोमेट्रिक (direct argentometric) विधि

Answer: (D)

Mohr's method is a direct argentometric precipitation titration used for determining halides (Cl- and Br-). The neutral halide solution (pH 6.5 to 9.0) is titrated directly with standard silver nitrate (AgNO3) using potassium chromate (K2CrO4) as indicator. Silver chloride precipitates out first due to its lower solubility product. Once all chloride is consumed, the first excess drop of Ag+ precipitates red-brown silver chromate (Ag2CrO4), signaling the endpoint.

मोहर विधि में उदासीन से हल्के क्षारीय (alkaline) pH पर AgNO₃ से हैलाइड (halide) अनुमापित करते हैं। समापन बिंदु (endpoint) पर Ag₂CrO₄ का ईंट-लाल अवक्षेप (brick-red precipitate) बनता है।

🔒

Unlock Full Document

Get instant access to all questions, solutions, and PDF download.

Login to Unlock

How to Download RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP PDF?

1. This is a Premium PDF. You need to unlock it first.
2. Choose a suitable plan from the options above.
3. Once unlocked, the download button will become active immediately without any ads.

What You Will Get in RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP PDF?

• ✔ A high-quality PDF of RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP with proper formatting
• ✔ Easy to read offline on mobile, tablet, or desktop
• ✔ Great for revision, practice, and quick reference
• ✔ Additional learning support with related videos and resources linked on this page
• ✔ Supports our mission: “Knowledge for Everyone”

Why Choose Solotutes?

At Solotutes, we provide access to notes, quizzes, MCQs, one-liners, and tests for multiple exams. By downloading RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP in PDF format, you not only get valuable material but also become part of a growing community of learners. We regularly update our posts with videos, explanations, and extra content to help you understand topics better.

FAQs – RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP Download

Q. Is this PDF really free?
✅ Yes! Free resources are completely free. Premium resources require a one-time unlock or pass.

Q. Do I need to sign up?
❌ For free PDFs, no account is needed. For premium tests, login is required to verify your purchase.

Q. Can I share this PDF with my friends?
✔ Yes, please share and help others learn too.

About Solotutes

Solotutes.com is dedicated to students preparing for competitive exams, schools, and universities. We provide free PDFs, quizzes, MCQs, notes, and one-liners to make learning easy and accessible.