Download PDF – RRB PH UT24 – Hospital Pharmacy Practice Test 1: Organization, PTC & Drug Distribution Systems

RRB PH UT24 – Hospital Pharmacy Practice Test 1: Organization, PTC & Drug Distribution Systems

Q1. Which vaccine is freeze-sensitive and loses potency if frozen?

A) Oral Polio Vaccine (OPV)

B) Measles vaccine

C) Tetanus Toxoid (TT) / Pentavalent vaccine

D) Yellow Fever vaccine

Q1. कौन-सी वैक्सीन जमने पर अपनी प्रभावकारिता (potency) खो देती है?

A) ओरल पोलियो वैक्सीन (OPV)

B) खसरा (Measles) वैक्सीन

C) टेटनस टॉक्सोइड (TT) / पेंटावैलेंट वैक्सीन

D) यलो फीवर वैक्सीन

Answer: (C)

Adsorbed vaccines containing aluminum adjuvants (e.g., Tetanus Toxoid, DPT, Hepatitis B, and Pentavalent vaccine) are strictly freeze-sensitive. Freezing causes irreversible denaturation and aggregation of the aluminum mineral adjuvant, which detaches from the antigen, destroying vaccine potency and inducing sterile abscesses upon injection. In contrast, OPV and Measles are live attenuated vaccines that safely tolerate freezing.

एल्यूमीनियम-एडजुवेंटेड (Aluminium-adjuvanted) TT/पेंटावैलेंट जैसी वैक्सीनें जमने के प्रति संवेदनशील (freeze-sensitive) होती हैं; जमने से इनकी प्रभावकारिता को स्थायी नुकसान पहुँच सकता है।

Q2. What temperature range defines 'Cold' storage in pharmacopoeial terminology?

A) Below 0°C

B) -10°C to -2°C

C) 8°C to 15°C

D) 2°C to 8°C

Q2. फार्माकोपिया की शब्दावली में 'Cold' (ठंडा) भंडारण का तापमान कितना होता है?

A) 0°C से कम

B) −10°C से −2°C

C) 8°C से 15°C

D) 2°C से 8°C

Answer: (D)

According to standard pharmacopoeial definitions (IP/USP/WHO): 'Cold' refers to any temperature between 2°C and 8°C (36°F to 46°F), which represents standard domestic refrigerator temperatures required for cold-chain biologicals, insulin, and vaccines. A 'Cool' place denotes 8°C to 15°C, 'Room Temperature' represents 15°C to 30°C, and a 'Freezer' maintains temperatures between -20°C and -10°C.

फार्माकोपिया की शब्दावली में 'Cold' = 2–8°C; 'Cool' = 8–15°C और कमरे का तापमान (room temperature) सामान्यतः 15–30°C होता है।

Q3. How should frozen ice packs be conditioned before vaccine transport?

A) Immersed immediately in hot water until melted

B) Conditioned at room temperature until the ice rattles and water droplets form on the surface

C) Covered with powdered sodium chloride to accelerate chilling

D) Placed directly against vaccine vials without intervening barriers

Q3. वैक्सीन परिवहन से पहले जमे हुए आइस पैक (frozen ice packs) को कैसे अनुकूलित (condition) किया जाता है?

A) गर्म पानी में डालकर तुरंत पिघलाना

B) कमरे के तापमान पर पसीने की बूँदें (sweat droplets) और बर्फ खड़खड़ाने (ice rattling) की आवाज़ आने तक रखना

C) सोडियम क्लोराइड पाउडर लगाना

D) वायल के सीधे संपर्क में रखना

Answer: (B)

When fresh frozen ice packs are removed from a -20°C freezer, their surface temperature is well below 0°C. If freeze-sensitive vaccines touch them directly, they can freeze and be ruined. Ice packs must therefore undergo 'conditioning'—laid out at ambient room temperature until they sweat and the ice rattles inside upon shaking—before being loaded into the carrier.

जमे हुए आइस पैक को कमरे के तापमान पर पसीने की बूँदें और बर्फ खड़खड़ाने की आवाज़ आने तक अनुकूलित किया जाता है; जमने-संवेदनशील वैक्सीनों से सीधा संपर्क रोकें।

Q4. Which drugs require secure, double-locked storage in the pharmacy?

A) Schedule P drugs (biological shelf-life substances)

B) Schedule G drugs (hormonal agents)

C) Schedule X and Narcotic Drugs (NDPS substances)

D) Schedule C1 non-parenteral biological products

Q4. फार्मेसी में किन दवाओं को सुरक्षित, दोहरे ताले वाली अलमारी में रखना आवश्यक है?

A) अनुसूची P (Schedule P) दवाएँ

B) अनुसूची G (Schedule G) दवाएँ

C) अनुसूची X और NDPS नारकोटिक दवाएँ

D) अनुसूची C1 की गैर-पैरेंट्रल जैविक (biological) दवाएँ

Answer: (C)

Under the Drugs and Cosmetics Act 1940 and the NDPS Act 1985, potent psychotropic drugs and Schedule X/narcotic analgesics (e.g., morphine, fentanyl, pethidine) must be stored in a sturdy, double-locked safe or steel cupboard permanently anchored to the building structure. The keys must remain in the personal custody of the registered pharmacist in charge, and daily reconciliations are legally mandated.

अनुसूची X तथा नियंत्रित नारकोटिक दवाओं को लागू नियमों के अनुसार सुरक्षित/दोहरे ताले वाले भंडारण (locked storage) में रखा जाता है; सटीक आवश्यकताएँ दवा की श्रेणी पर निर्भर करती हैं।

Q5. Which document communicates medication orders for an admitted inpatient to the pharmacist?

A) Hospital Procurement Invoice

B) Physician's Order Sheet / Inpatient Medication Chart

C) Surgical Consent Form

D) Formulary Inclusion Request Form

Q5. अस्पताल में भर्ती मरीज (inpatient) के दवा आदेश फार्मासिस्ट तक किस दस्तावेज़ से पहुँचते हैं?

A) अस्पताल खरीद चालान (Hospital Procurement Invoice)

B) चिकित्सक का आदेश पत्र / इनपेशेंट मेडिकेशन चार्ट

C) सर्जिकल सहमति प्रपत्र (Surgical Consent Form)

D) सूत्रवली समावेशन अनुरोध प्रपत्र (Formulary Inclusion Request Form)

Answer: (B)

The Physician's Order Sheet (Inpatient Medication Administration Record / BHT chart) is the legal medical record where the treating physician writes specific drug orders (drug name, dose, route, frequency, and duration). The hospital pharmacist reviews this direct record (or its digital CPOE copy) for prospective safety screening before medications are dispensed.

इनपेशेंट मेडिकेशन चार्ट या आदेश पत्र चिकित्सक के दवा आदेशों (medication orders) का औपचारिक रिकॉर्ड है।

Q6. Which refrigerator is used to store EPI vaccines at district and primary health centres?

A) Ice-Lined Refrigerator (ILR)

B) Domestic direct-cool freezer

C) Thermoelectric countertop cooler

D) Dry ice sublimation chest

Q6. जिला और प्राथमिक स्वास्थ्य केंद्रों पर EPI वैक्सीन किस रेफ्रिजरेटर में रखी जाती हैं?

A) आइस-लाइंड रेफ्रिजरेटर (ILR)

B) घरेलू डायरेक्ट-कूल फ्रीजर

C) थर्मोइलेक्ट्रिक काउंटरटॉप कूलर

D) ड्राई आइस सब्लिमेशन चेस्ट

Answer: (A)

An Ice-Lined Refrigerator (ILR) is a specialized, top-opening cold-chain unit engineered to maintain an internal temperature between +2°C and +8°C even during prolonged electrical power failures (up to 24–48 hours). The inner lining of cold water tubes or ice plates absorbs heat leaks, preventing the chamber from exceeding safe thermal limits.

ILR, UIP/EPI वैक्सीनों को +2°C से +8°C पर रखता है और बिजली कटौती (power interruptions) के दौरान भी तापमान बनाए रखने में मदद करता है।

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