Download PDF – RRB PH UT15 – Pharmaceutical Chemistry Practice Test 2: Organic Chemistry & Heterocycles

RRB PH UT15 – Pharmaceutical Chemistry Practice Test 2: Organic Chemistry & Heterocycles

Q1. Ibuprofen’s systematic IUPAC name is?

A) 2-(4-isobutylphenyl)acetic acid

B) 2-(4-isobutylphenyl)propanoic acid

C) 2-(3-isobutylphenyl)propanoic acid

D) 4-(2-methylpropyl)benzoic acid

Q1. इबुप्रोफेन (Ibuprofen) का व्यवस्थित IUPAC नाम क्या है?

A) 2-(4-आइसोब्यूटाइलफेनिल)एसीटिक अम्ल

B) 2-(4-आइसोब्यूटाइलफेनिल)प्रोपेनोइक अम्ल

C) 2-(3-आइसोब्यूटाइलफेनिल)प्रोपेनोइक अम्ल

D) 4-(2-मिथाइलप्रोपाइल)बेंजोइक अम्ल

Answer: (B)

The chemical structure of Ibuprofen consists of a propanoic acid backbone [-CH(CH3)COOH] substituted at the C2 position with a 4-isobutylphenyl group [4-(2-methylpropyl)phenyl]. Therefore, its official IUPAC name is 2-[4-(2-methylpropyl)phenyl]propanoic acid, commonly written as 2-(4-isobutylphenyl)propanoic acid.

इबुप्रोफेन में प्रोपेनोइक अम्ल मुख्य श्रृंखला है और C2 पर 4-(2-मिथाइलप्रोपाइल)फेनिल समूह जुड़ा है। इसका नाम 2-[4-(2-मिथाइलप्रोपाइल)फेनिल]प्रोपेनोइक अम्ल है; प्रचलित रूप 2-(4-आइसोब्यूटाइलफेनिल)प्रोपेनोइक अम्ल भी लिखा जाता है।

Q2. Paracetamol’s systematic IUPAC name is?

A) N-(2-hydroxyphenyl)acetamide

B) 4-Aminophenol

C) 2-(4-hydroxyphenyl)ethanamide

D) N-(4-hydroxyphenyl)acetamide

Q2. पैरासिटामोल (एसीटामिनोफेन) का व्यवस्थित IUPAC नाम क्या है?

A) N-(2-हाइड्रॉक्सीफेनिल)एसीटामाइड

B) 4-अमीनोफेनॉल

C) 2-(4-हाइड्रॉक्सीफेनिल)एथेनामाइड

D) N-(4-हाइड्रॉक्सीफेनिल)एसीटामाइड

Answer: (D)

Paracetamol consists of an aniline core with a phenolic hydroxyl group at the para (C4) position and an acetylated amino group. The principal functional group is an acetamide (ethanamide) where the nitrogen is substituted by a 4-hydroxyphenyl ring, yielding the systematic IUPAC designation N-(4-hydroxyphenyl)acetamide (or N-(4-hydroxyphenyl)ethanamide).

पैरासिटामोल में para-हाइड्रॉक्सीफेनिल समूह से जुड़ा एसीटामाइड भाग होता है। व्यवस्थित नाम N-(4-हाइड्रॉक्सीफेनिल)एसीटामाइड है।

Q3. Which fused benzene–pyridine ring occurs in chloroquine and ciprofloxacin?

A) Quinoline

B) Purine

C) Isoquinoline

D) Indole

Q3. क्लोरोक्वीन (Chloroquine) और सिप्रोफ्लोक्सासिन (Ciprofloxacin) में कौन-सा संलयित बेंजीन–पाइरीडीन वलय (fused benzene–pyridine ring) होता है?

A) क्विनोलिन

B) प्यूरिन

C) आइसोक्विनोलिन

D) इंडोल

Answer: (A)

Quinoline (benzo[b]pyridine) is a fused heterocyclic aromatic system consisting of a benzene ring ortho-fused to a pyridine ring (with nitrogen at position 1). It serves as the core pharmacophore for 4-aminoquinoline antimalarials (chloroquine) and the fluoroquinolone antibiotic scaffold (derived from 1,4-dihydro-4-oxoquinoline). Isoquinoline has the nitrogen at position 2.

क्विनोलिन बेंजीन और पाइरीडीन का ortho-संघनित एरोमैटिक तंत्र है; क्लोरोक्वीन तथा फ्लुओरोक्विनोलोन औषधियों में इसका मूल ढाँचा पाया जाता है। आइसोक्विनोलिन में N की स्थिति अलग होती है।

Q4. What is the ring name of thiazole in thiamine and sulfathiazole?

A) 1,4-Thiazine

B) 1,3-Thiazole

C) 1,2-Diazole

D) 1,3-Oxazole

Q4. थायामीन (Thiamine) और सल्फाथायाज़ोल (Sulfathiazole) में थायाज़ोल वलय का नाम क्या है?

A) 1,4-थायाज़ीन

B) 1,3-थायाज़ोल

C) 1,2-डायाज़ोल

D) 1,3-ऑक्साज़ोल

Answer: (B)

Thiazole is a five-membered aromatic heterocycle containing both sulfur and nitrogen atoms separated by one carbon atom. Numbering starts at the sulfur heteroatom as position 1 and proceeds toward nitrogen as position 3, giving the systematic IUPAC Hantzsch-Widman designation 1,3-thiazole. A sulfur at 1 and nitrogen at 2 constitutes an isothiazole (1,2-thiazole).

थायाज़ोल पाँच-सदस्यीय एरोमैटिक वलय है जिसमें S स्थान 1 और N स्थान 3 पर होते हैं; 1,2 व्यवस्था आइसोथायाज़ोल कहलाती है।

Q5. Which 1,3-dinitrogen five-membered ring is found in histamine and metronidazole?

A) Triazole

B) Imidazole

C) Pyrrole

D) Pyrazole

Q5. हिस्टामिन (Histamine) और मेट्रोनिडाज़ोल (Metronidazole) में कौन-सा 1,3-डाइनाइट्रोजन पाँच-सदस्यीय वलय पाया जाता है?

A) ट्रायाज़ोल

B) इमिडाज़ोल

C) पाइरोल

D) पाइराज़ोल

Answer: (B)

Imidazole (1,3-diazole) is a planar five-membered aromatic heterocycle containing two nitrogen heteroatoms: a pyrrole-like >NH at position 1 and a pyridine-like =N- at position 3. It constitutes the core aromatic nucleus of the essential amino acid histidine, histamine, cimetidine, and the 5-nitroimidazole antiparasitics (metronidazole, tinidazole). Pyrazole is the 1,2-diazole isomer.

इमिडाज़ोल 1,3-डायाज़ोल है, जिसमें एक पाइरोल-जैसा –NH और एक पाइरीडीन-जैसा N होता है। हिस्टामिन और मेट्रोनिडाज़ोल में यह मूल वलय है।

Q6. Which benzene–pyrrole fused ring is present in tryptophan and indomethacin?

A) Indole

B) Benzofuran

C) Benzimidazole

D) Quinoline

Q6. ट्रिप्टोफैन (Tryptophan) और इंडोमेथासिन (Indomethacin) में कौन-सा संलयित बेंजीन–पाइरोल वलय (fused benzene–pyrrole ring) उपस्थित होता है?

A) इंडोल

B) बेंज़ोफ्यूरान

C) बेंज़िमिडाज़ोल

D) क्विनोलिन

Answer: (A)

Indole (benzo[b]pyrrole) consists of a six-membered benzene ring fused across positions 2 and 3 of a five-membered pyrrole ring. It is the core heterocyclic nucleus found in the neurotransmitter serotonin (5-hydroxytryptamine), the amino acid L-tryptophan, plant auxins, the NSAID indomethacin, and ergot/vinca alkaloids. Benzimidazole contains an additional nitrogen at position 3.

इंडोल बेंजीन और पाइरोल के संलयन से बनता है; ट्रिप्टोफैन, सेरोटोनिन और इंडोमेथासिन में इसका ढाँचा मिलता है।

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