Download PDF – RRB PH UT08 – Pharmaceutics Practice Test 4: Posology & Packaging

RRB PH UT08 – Pharmaceutics Practice Test 4: Posology & Packaging

Q1. According to Young's rule of pediatric posology, what is the calculated dose for an 8-year-old child if the standard adult dose of the drug is 500 mg?

A) 150 mg

B) 200 mg

C) 250 mg

D) 125 mg

Q1. Young के बाल-औषधि-मात्रा नियम के अनुसार, यदि मानक वयस्क खुराक 500 mg है, तो 8 वर्ष के बच्चे की गणना की गई खुराक कितनी होगी?

A) 150 mg

B) 200 mg

C) 250 mg

D) 125 mg

Answer: (B)

Young's rule calculates pediatric dosage based on age for children aged 1 to 12 years using the formula: Pediatric Dose = [Age in years / (Age in years + 12)] × Adult Dose. Substituting the values: Dose = [8 / (8 + 12)] × 500 mg = [8 / 20] × 500 mg = 0.40 × 500 mg = 200 mg.

Young के नियम के अनुसार बाल खुराक = [आयु (वर्ष) / (आयु + 12)] × वयस्क खुराक। इसलिए [8/(8+12)] × 500 mg = 200 mg। यह पारंपरिक अनुमानित सूत्र है; वास्तविक दवा-खुराक में वर्तमान clinical guidance और रोगी-विशिष्ट कारक प्राथमिक होते हैं।

Q2. Which pediatric dosage formula calculates the child's dose based strictly on weight in pounds divided by 150?

A) Clark's rule

B) Fried's rule

C) Dilling's rule

D) Cowling's rule

Q2. कौन-सा बाल-खुराक सूत्र बच्चे की खुराक की गणना केवल पाउंड में वजन को 150 से विभाजित करके करता है?

A) Clark का नियम

B) Fried का नियम

C) Dilling का नियम

D) Cowling का नियम

Answer: (A)

Clark's rule calculates the pediatric dose based on body weight in pounds: Pediatric Dose = [Weight in pounds (lb) / 150] × Adult Dose. If weight is expressed in kilograms: Pediatric Dose = [Weight in kg / 70] × Adult Dose. Dilling's and Cowling's rules are age-based, while Fried's rule calculates doses for infants up to 1-2 years based on age in months.

Clark का नियम शरीर के वजन पर आधारित पारंपरिक सूत्र है: बाल खुराक = [वजन (पाउंड) / 150] × वयस्क खुराक। किलोग्राम में प्रचलित अनुमानित रूप [वजन (kg)/70] × वयस्क खुराक है। Dilling और Cowling आयु-आधारित नियम हैं; Fried का नियम आयु महीनों में लेता है।

Q3. Using Dilling's rule, what proportion of the adult dose should be administered to a 10-year-old child?

A) 40%

B) 33%

C) 25%

D) 50%

Q3. Dilling के नियम के अनुसार, 10 वर्ष के बच्चे को वयस्क खुराक का कितना अनुपात देना चाहिए?

A) 40%

B) 33%

C) 25%

D) 50%

Answer: (D)

Dilling's rule calculates pediatric doses for children between 4 and 20 years using the formula: Child Dose = [Age in completed years / 20] × Adult Dose. For a 10-year-old child: Proportion = 10 / 20 = 0.50, which corresponds to exactly 50% of the adult dose.

Dilling का पारंपरिक सूत्र: बाल खुराक = [आयु (पूर्ण वर्ष)/20] × वयस्क खुराक। 10 वर्ष के लिए 10/20 = 0.50, अर्थात वयस्क खुराक का 50%। यह केवल शैक्षणिक अनुमान है, व्यक्तिगत prescribing का विकल्प नहीं।

Q4. An infant aged 9 months requires medication. According to Fried's rule, what dose should be administered if the adult dose is 300 mg?

A) 12 mg

B) 36 mg

C) 25 mg

D) 18 mg

Q4. 9 महीने के शिशु को दवा देनी है। Fried के नियम के अनुसार, यदि वयस्क खुराक 300 mg है, तो शिशु की खुराक कितनी होगी?

A) 12 mg

B) 36 mg

C) 25 mg

D) 18 mg

Answer: (D)

Fried's rule is specifically applied to infants under 2 years (24 months) of age: Infant Dose = [Age in months / 150] × Adult Dose. Substituting the given values: Infant Dose = [9 / 150] × 300 mg = 9 × 2 mg = 18 mg.

Fried का पारंपरिक सूत्र: शिशु खुराक = [आयु महीनों में/150] × वयस्क खुराक। इसलिए (9/150) × 300 mg = 18 mg। वास्तविक शिशु खुराक के लिए इस पुराने नियम पर अकेले निर्भर नहीं करना चाहिए।

Q5. What is the proof strength of an ethanol solution containing 70% v/v ethyl alcohol according to the Indian excise system?

A) 122.7° Proof (22.7° Over Proof)

B) 110.5° Proof (10.5° Over Proof)

C) 85.4° Proof (14.6° Under Proof)

D) 57.1° Proof (42.9° Under Proof)

Q5. भारतीय प्रूफ प्रणाली के अनुसार, 70% v/v एथिल अल्कोहल वाले घोल की प्रूफ स्ट्रेंथ कितनी है?

A) 122.7° Proof (22.7° Over Proof)

B) 110.5° Proof (10.5° Over Proof)

C) 85.4° Proof (14.6° Under Proof)

D) 57.1° Proof (42.9° Under Proof)

Answer: (A)

Using the stated textbook factor, proof strength = (% v/v ethanol × 1.753). For 70% v/v: 70 × 1.753 = 122.71° Proof, approximately 122.7° Proof, or 22.7° Over Proof. Exact values may depend on temperature and the applicable alcoholometric table.

दिए गए पाठ्यपुस्तकीय गुणक 1.753 से proof strength = 70 × 1.753 = 122.71° Proof, अर्थात लगभग 122.7° Proof या 22.7° Over Proof। वास्तविक प्रमाण-शक्ति तापमान और आधिकारिक alcoholometric tables पर निर्भर कर सकती है।

Q6. In what proportion must 90% alcohol and 40% alcohol be mixed using the alligation alternate method to produce a 60% alcohol solution?

A) 1 part of 90% and 2 parts of 40%

B) 2 parts of 90% and 3 parts of 40%

C) 3 parts of 90% and 1 part of 40%

D) 4 parts of 90% and 5 parts of 40%

Q6. 60% अल्कोहल घोल बनाने के लिए alligation alternate विधि से 90% और 40% अल्कोहल को किस अनुपात में मिलाना चाहिए?

A) 90% अल्कोहल का 1 भाग और 40% अल्कोहल के 2 भाग

B) 90% अल्कोहल के 2 भाग और 40% अल्कोहल के 3 भाग

C) 90% अल्कोहल के 3 भाग और 40% अल्कोहल का 1 भाग

D) 90% अल्कोहल के 4 भाग और 40% अल्कोहल के 5 भाग

Answer: (B)

Applying the alligation alternate cross-method with target concentration 60%: Parts of 90% alcohol needed = |60 - 40| = 20 parts; Parts of 40% alcohol needed = |90 - 60| = 30 parts. Simplifying the ratio of 90% to 40% alcohol gives 20 : 30, which reduces to 2 : 3 (2 parts of 90% and 3 parts of 40%).

Alligation alternate में भागों का अनुपात = (60−40):(90−60) = 20:30 = 2:3। अतः 90% अल्कोहल के 2 भाग और 40% अल्कोहल के 3 भाग मिलाएँ।

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