Download PDF – RRB Pharmacist (Entry Grade) CBT Mock Test 1

RRB Pharmacist (Entry Grade) CBT Mock Test 1

Q1. Which of the following equations is used to determine the rate of drug dissolution from a solid dosage form?

A) Henderson-Hasselbalch equation

B) Michaelis-Menten equation

C) Arrhenius equation

D) Noyes-Whitney equation

Answer: (D)

The Noyes-Whitney equation describes the rate of dissolution of solid drugs: dM/dt = (D*A/h)*(Cs - C). Henderson-Hasselbalch calculates pH/pKa, Michaelis-Menten describes enzyme kinetics, and Arrhenius relates rate constants to temperature.

Q2. Under the Indian Pharmacopoeia, which type of glass is specifically classified as 'Highly Resistant Borosilicate Glass'?

A) Type IV (NP)

B) Type III

C) Type I

D) Type II

Answer: (C)

Type I is Borosilicate glass (highly resistant, used for parenteral preparations). Type II is treated soda-lime glass, Type III is regular soda-lime glass, and Type IV (NP) is non-parenteral glass.

Q3. What is the primary role of Croscarmellose sodium in tablet formulation?

A) Glidant

B) Binder

C) Lubricant

D) Superdisintegrant

Answer: (D)

Croscarmellose sodium (cross-linked sodium carboxymethylcellulose) acts as a superdisintegrant by rapid water wicking and swelling mechanisms to rupture the tablet matrix.

Q4. According to Young's rule, what is the formula for calculating a child's dose?

A) Child dose = [Age in years / 150] * Adult dose

B) Child dose = [Weight in pounds / 150] * Adult dose

C) Child dose = [Age in years / (Age in years + 12)] * Adult dose

D) Child dose = [Age in months / 150] * Adult dose

Answer: (C)

Young's rule: Age in years / (Age + 12) * Adult dose. Clark's rule is based on weight in pounds: (Weight / 150) * Adult dose. Fried's rule is for infants: (Age in months / 150) * Adult dose.

Q5. Which mill operates on the combined principles of 'Impact and Attrition' for fine size reduction?

A) Hammer mill only

B) Roller mill only

C) Edge runner mill

D) Fluid energy mill and Ball mill

Answer: (D)

Both Ball mill and Fluid energy mill operate on both impact and attrition. Hammer mill operates primarily on impact, while Roller mill operates on compression/attrition.

Q6. The phenomenon where an emulsion separates into two distinct layers, with the concentrated globules rising to the surface, is known as:

A) Cracking

B) Flocculation

C) Phase inversion

D) Creaming

Answer: (D)

Creaming is the upward or downward movement of dispersed droplets to form a concentrated layer, which is reversible upon shaking. Cracking (breaking) is irreversible destruction of the protective film.

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