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The amorphous solid state possesses several advantages in comparison to the crystalline state which allow enhanced forms of drugs to be produced. Many drugs when generated as an amorphous form will exhibit one or more of the following properties: Solubility The amorphous state is thermodynamically the form with the highest solubility. Consequently, amorphous forms will exhibit a greater solubility in a solvent than any crystalline form. Solubility advantages of factors >1000 have been observed between crystalline and amorphous drugs. The increased solubility of amorphous actives can lead to dramatically increased intrinsic dissolution rates when compared to crystalline forms. Wettability For…
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