Diflunisal is a diflourophenyl derivative of -

c) Salicylic acid | Diflunisal is an analgesic drug, a derivative of salicylic acid. Brand name dolobid.

Drug used in gout is -

c) Indomethacin | Indomethacin is the drug of choice in gout. It is one among the synthetic drug.

Oxyphenbutazone is active metabolite of following -

c) Phenylbutazone | Phenylbutazone is metabolised in liver to oxyphenebutazone, which also pharmacologically active.

Carbomal, used in mild insomnia is a -

c) Monoureides | Carbomol is belongs to the class monoureides and it is used for mild sleep disorder (insomnia).

Cocaine is rarely used due to its -

c) Toxicity and addiction | Use of cocaine is restricted due to its addiction (habit forming properties)

Largactil is a a common name for -

b) Chlorpromazine | Chlorpromazine is belongs to antipsychotic class (dopamine antagonist)

Which drug is preferred to give to bed wetted children?

b) Imipramine | Imipramine is a Tricyclic antidepressant drug used for bed wetting.

Which one of these drug is mono-amine oxidase (MAO) inhibitor?

d) Tranylcypromine | MAO inhibitors are used in depression. They includes tranylcypromine, phenelgine, isocarboxazide, linezolid etc.

b) 1,3,7-trimethyl xanthene | Caffeine is 1,3,7-trimethyl xanthene, theophylline is 1,3-dimethyl xanthene and theobromine is 1,3- dimethyl xanthene.

Parkinsonism occurs due to -

b) Depletion of dopamine | The loss of dopamine in brain is cause for parkinson's disease.

Naphazoline is used in -

c) Nasal congestion | Naphazoline is a sympathomimetic agent. It is used as nasal decongestion agent.

Hyoscine (scopolamine) differs structurally from atropine -

c) Hyoscine possesses epoxide linkage between carbon 6 and 7 | Scopolamine and atropine both are tropane alkaloids. Presence of epoxide linkage between carbon 6 and 7 is the structural difference between these two. (See image below)

Quinidine acts as antiarrhythmic drug by -

c) Sodium channel blockade | Quinidine is a stereoisomer of quinine. It acts by blocking sodium channels.

Mannitol acts as diuretic by-

a) Increasing the osmotic pressor in renal tubule | Mannitol (manna sugar) is used clinically as diuretic and acts as osmotic agents (osmotherapy).

Sulphonylureas act as oral hypoglycaemic agent by -

c) Stimulating insulin secretion | Sulphonylureas are the class of anti-diabetic drugs (type 2 diabetes) they act by increasing insulin release from beta cells of pancreases.

Antithyroid drugs decrease the synthesis of thyroxine by -

c) Interfering with incorporation of iodide thyroglobulin | Antithyroid drugs (carbimazole, methimazole, and propyl thiouracil) act by inhibiting iodination of thyroglobulin.

Which one of these is an anabolic steroid?

c) Stanozolol | Stanozolol, danozol, nandrolone, metenolone etc. are anabolic steroids.

Hydrocortisone differ from cortisone in possessing -

c) Hydroxy group in place of keto group at C-11 | At the C-11 position cortisone has C>=O group and hydrocortisone has >-OH group

Sulphonamides act as antibacterial drug due to -

a) Free amino group | The free amino group in sulphonamides is responsible for their abtibacterial action.

The structure of penicillin consists of

c) Thiazolidine and β -lactam ring | Penicillin consists of thiazolidine and &beta; - lactam ring.

Which one if these antibiotics is effective in the treatment of intestinal amoebiasis?

b) Paromomycin | Paromomycin is an aminoglycosides antibiotic, used to treat intestinal amoebiasis infections.

Vermox is a common brand for -

c) Mebendazole | Vermox is the brand name for mebendazole which is anti-worm (anthelmintic) drug.

Which one of these drugs is used as an opthalmic diagnostic agent?

a) Fluorescein sodium | Fluoresceine is orange red, non toxic and acidic dye of xanthene series. It is used as opthalmic diagnostic agents.

Evans blue is used to determine -

c) Blood volume | Evans blue is an azo dye which has very high affinity for serum albumin. Because of thus it is used to determine blood volume.

Which one of these vitamin is a naphthaquinone derivative?

c) Vitamin K | Vitamin K is a group of structurally similar fat soluble vitamins having naphthaquinone ring (vitamin K1 and K2)

Chemical structure of halothene is-

a) CH3-CHBrCl | Halothane (Fluothane) is an inhalant general anesthatic.chemically it is 2-bromo-2-chloro-1,1,1-trifluoroethane.

The number of nitrogen atom in benzimidazole is :

a) 2 in the same ring | 2 nitogen atoms are present in one ring (same ring) of benzimidazole.

which one of these antineoplastic (anticancer) drugs contains platinum?

c) Cisplatin | Cisplatin is diamino-dichloro-platinum, anticancer drug. Now also include carbaplatin, oxaloplatin.

The organophosphate poisoning is treated by

c) Pralidoxime | Pralidoxime is used to treat the poisoning caused by organophosphate and ACH inhibitors.

Propranolol, atenolol, and metoprolol are similar in structure due to possession of-

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Q.14. Propranolol, atenolol, and metoprolol are similar in structure due to possession of-

Basic nucleus
Side chain (2-hydroxy-3-isopropylaminopropoxy)
Alkyl group
All of these

Answer: (b) Side chain (2-hydroxy-3-isopropylaminopropoxy)
Explanation: The side chain is same in metaprolol, atenolol, and propranolol. All these three are β -blockers.

Practice Test #1 | Pharmaceutical Chemistry-II (organic)

30 Questions 964 Attempts 38.72K Seen

This practice test includes objective questions (MCQs) from pharmaceutical organic chemistry (pharma chemistry 2) for D.Pharma and B.pharma students. These questions are very helpful for competitive as well as (objective questions based) university exams.
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Q.No.	Que title	Option 1 (a)	Option 2 (b)	Option 3 (c)	Option 4 (d)
1	Diflunisal is a diflourophenyl derivative of -	Acetic acid	Propionic acid	Salicylic acid	Pyrazole
2	Drug used in gout is -	Ibuprofen	Oxyphenbutazone	Indomethacin	None of the above
3	Oxyphenbutazone is active metabolite of following -	Sulphinpyrazole	Pyrazole	Phenylbutazone	None of the above
4	Carbomal, used in mild insomnia is a -	Monoguanide	Barbiturate	Monoureides	None of the above
5	Cocaine is rarely used due to its -	Toxicity	Irritatant action	Toxicity and addiction	Incompatibility
6	Largactil is a a common name for -	Prochlorperazine	Chlorpromazine	Perphenazine	Promethazine
7	Which drug is preferred to give to bed wetted children?	Amitriptyline	Imipramine	Phenelzine	Isocarboxazide
8	Which one of these drug is mono-amine oxidase (MAO) inhibitor?	Imipramine	Lithium citrate	Amitriptyline	Tranylcypromine
9	Caffeine is a -	3,7-dimethyl xanthene	1,3,7-trimethyl xanthene	1,3-dimethyl xanthene	None of the above
10	Parkinsonism occurs due to -	Excess of dopamine	Depletion of dopamine	Depletion of epinephrine	None of the above
11	Naphazoline is used in -	Asthma	Hypotension	Nasal congestion	Hay fever
12	Hyoscine (scopolamine) differs structurally from atropine -	Hyoscine is not a ester	Hyoscine is an ester of different alcohol and tropic acid	Hyoscine possesses epoxide linkage between carbon 6 and 7	None of the above
13	Quinidine acts as antiarrhythmic drug by -	Calcium channel blockade	β -receptor blockade	Sodium channel blockade	None of the above
14	Propranolol, atenolol, and metoprolol are similar in structure due to possession of-	Basic nucleus	Side chain (2-hydroxy-3-isopropylaminopropoxy)	Alkyl group	All of these
15	Mannitol acts as diuretic by-	Increasing the osmotic pressor in renal tubule	Increasing the rate if glomerular filtration	Inhibiting the reabsorption of sodium ion	None of the above
16	Sulphonylureas act as oral hypoglycaemic agent by -	Increasing the metabolism of carbohydrate	Utilising the Glucose	Stimulating insulin secretion	None of the above
17	Antithyroid drugs decrease the synthesis of thyroxine by -	Decreasing the availability of amino acid	Destroying the cell in thyroid gland	Interfering with incorporation of iodide thyroglobulin	All of these
18	Which one of these is an anabolic steroid?	Testosterone propionate	Fluxymesterone	Stanozolol	None of the above
19	Hydrocortisone differ from cortisone in possessing -	Basic nucleus	Double bond	Hydroxy group in place of keto group at C-11	None of the above
20	Sulphonamides act as antibacterial drug due to -	Free amino group	Sulphonamide group	Benzene nucleus	None of the above
21	The structure of penicillin consists of	Thiozolidine	β -lactam	Thiazolidine and β -lactam ring	None of the above
22	Which one if these antibiotics is effective in the treatment of intestinal amoebiasis?	Streptomycin	Paromomycin	Ampicillin	Chloramphenicol
23	Vermox is a common brand for -	Thiabendazole	Piperazine	Mebendazole	Metronidazole
24	Which one of these drugs is used as an opthalmic diagnostic agent?	Fluorescein sodium	Congo red	Methelene blue	Indigo carmine
25	Evans blue is used to determine -	Liver function	kidney function	Blood volume	Ulceration in Eye cornea
26	Which one of these vitamin is a naphthaquinone derivative?	Vitamin C	Vitamin A	Vitamin K	Vitamin D
27	Chemical structure of halothene is-	CH₃-CHBrCl	CF₃ -CHCl-O-CHF₂	C₃H₇ - O- CH₃	CHF.Cl-CF₂-OCHF₂
28	The number of nitrogen atom in benzimidazole is :	2 in the same ring	3 in the same ring	1 in the five membered ring	2 in the different ring
29	which one of these antineoplastic (anticancer) drugs contains platinum?	Nitrogen mustard	Busulphan	Cisplatin	Daunorubicin
30	The organophosphate poisoning is treated by	Neostigmine	Physostigmine	Pralidoxime	Pyridostigmine

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