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The Study of drug, their machanism of action, pharmacological actions and their adverse effects

Pharmacodynamics

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  • A Heparin & Protamine
  • B Protamine & Zinc
  • C Heparin & Prothrombin
  • D All the above
Explanation: Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.
  • A Increases volume of distribution of the drug
  • B Generally makes the drug long acting
  • C Facilitates glomerular filtration of the drug
  • D Minimises drug interactions
  • A Canal of Schlemm
  • B Ciliary body
  • C Ciliary muscle
  • D Sphincter pupillae muscle
  • A Undergoes little first-pass metabolism
  • B Is incompletely absorbed
  • C Is freely water soluble
  • D Is completely absorbed
  • A Enalapril
  • B Menapril
  • C Thiazine
  • D Penicillin
  • A Dapsone
  • B Meperidine
  • C Phenytoin
  • D Chlorpheniramine
Explanation: N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.

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