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One Liner

Chemical alteration of an agent (drug) that occurs by virtue of the sojourn of the agent in a biological system.

Biotransformation

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  • A Weak acids
  • B Strong acids
  • C Weak Bases
  • D None of the above
Explanation:
because of enhanced disassociation weak acids
are excreted faster in basic (not acidic) urine.
  • A Adrenergic α1 agonists
  • B Adrenergic α1 antagonists
  • C Adrenergic α2 antagonists
  • D Adrenergic α2 agonists
  • A Tolerance
  • B Physical dependence
  • C Psychological dependence
  • D Idiosyncrasy
  • A Albumin
  • B acid glycoprotein
  • C Weak acids
  • D Heparin & Protamine
Explanation: Glycoprotein binds to basic drugs and albumin binds to many acidic drugs and a small number of basic drugs.
  • A Increases volume of distribution of the drug
  • B Generally makes the drug long acting
  • C Facilitates glomerular filtration of the drug
  • D Minimises drug interactions
  • A Heparin & Protamine
  • B Protamine & Zinc
  • C Heparin & Prothrombin
  • D All the above
Explanation: Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.

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