Q1. Diflunisal is a diflourophenyl derivative of -

• A) Acetic acid
• B) Propionic acid
• C) Salicylic acid
• D) Pyrazole

Answer: (C) Salicylic acid

Diflunisal is an analgesic drug, a derivative of salicylic acid. Brand name dolobid.

Q2. Drug used in gout is -

• A) Ibuprofen
• B) Oxyphenbutazone
• C) Indomethacin
• D) None of the above

Answer: (C) Indomethacin

Indomethacin is the drug of choice in gout. It is one among the synthetic drug.

Q3. Oxyphenbutazone is active metabolite of following -

• A) Sulphinpyrazole
• B) Pyrazole
• C) Phenylbutazone
• D) None of the above

Answer: (C) Phenylbutazone

Phenylbutazone is metabolised in liver to oxyphenebutazone, which also pharmacologically active.

Q4. Carbomal, used in mild insomnia is a -

• A) Monoguanide
• B) Barbiturate
• C) Monoureides
• D) None of the above

Answer: (C) Monoureides

Carbomol is belongs to the class monoureides and it is used for mild sleep disorder (insomnia).

Q5. Cocaine is rarely used due to its -

• A) Toxicity
• B) Irritatant action
• C) Toxicity and addiction
• D) Incompatibility

Answer: (C) Toxicity and addiction

Use of cocaine is restricted due to its addiction (habit forming properties)

Q6. Largactil is a a common name for -

• A) Prochlorperazine
• B) Chlorpromazine
• C) Perphenazine
• D) Promethazine

Answer: (B) Chlorpromazine

Chlorpromazine is belongs to antipsychotic class (dopamine antagonist)

Q7. Which drug is preferred to give to bed wetted children?

• A) Amitriptyline
• B) Imipramine
• C) Phenelzine
• D) Isocarboxazide

Answer: (B) Imipramine

Imipramine is a Tricyclic antidepressant drug used for bed wetting.

Q8. Which one of these drug is mono-amine oxidase (MAO) inhibitor?

• A) Imipramine
• B) Lithium citrate
• C) Amitriptyline
• D) Tranylcypromine

Answer: (D) Tranylcypromine

MAO inhibitors are used in depression. They includes tranylcypromine, phenelgine, isocarboxazide, linezolid etc.

Q9. Caffeine is a -

• A) 3,7-dimethyl xanthene
• B) 1,3,7-trimethyl xanthene
• C) 1,3-dimethyl xanthene
• D) None of the above

Answer: (B) 1,3,7-trimethyl xanthene

Caffeine is 1,3,7-trimethyl xanthene, theophylline is 1,3-dimethyl xanthene and theobromine is 1,3- dimethyl xanthene.

Q10. Parkinsonism occurs due to -

• A) Excess of dopamine
• B) Depletion of dopamine
• C) Depletion of epinephrine
• D) None of the above

Answer: (B) Depletion of dopamine

The loss of dopamine in brain is cause for parkinson's disease.

Q11. Naphazoline is used in -

• A) Asthma
• B) Hypotension
• C) Nasal congestion
• D) Hay fever

Answer: (C) Nasal congestion

Naphazoline is a sympathomimetic agent. It is used as nasal decongestion agent.

Q12. Hyoscine (scopolamine) differs structurally from atropine -

• A) Hyoscine is not a ester
• B) Hyoscine is an ester of different alcohol and tropic acid
• C) Hyoscine possesses epoxide linkage between carbon 6 and 7
• D) None of the above

Answer: (C) Hyoscine possesses epoxide linkage between carbon 6 and 7

Scopolamine and atropine both are tropane alkaloids. Presence of epoxide linkage between carbon 6 and 7 is the structural difference between these two. (See image below)

Q13. Quinidine acts as antiarrhythmic drug by -

• A) Calcium channel blockade
• B) β -receptor blockade
• C) Sodium channel blockade
• D) None of the above

Answer: (C) Sodium channel blockade

Quinidine is a stereoisomer of quinine. It acts by blocking sodium channels.

Q14. Propranolol, atenolol, and metoprolol are similar in structure due to possession of-

• A) Basic nucleus
• B) Side chain (2-hydroxy-3-isopropylaminopropoxy)
• C) Alkyl group
• D) All of these

Answer: (B) Side chain (2-hydroxy-3-isopropylaminopropoxy)

The side chain is same in metaprolol, atenolol, and propranolol. All these three are β -blockers.

Q15. Mannitol acts as diuretic by-

• A) Increasing the osmotic pressor in renal tubule
• B) Increasing the rate if glomerular filtration
• C) Inhibiting the reabsorption of sodium ion
• D) None of the above

Answer: (A) Increasing the osmotic pressor in renal tubule

Mannitol (manna sugar) is used clinically as diuretic and acts as osmotic agents (osmotherapy).

Q16. Sulphonylureas act as oral hypoglycaemic agent by -

• A) Increasing the metabolism of carbohydrate
• B) Utilising the Glucose
• C) Stimulating insulin secretion
• D) None of the above

Answer: (C) Stimulating insulin secretion

Sulphonylureas are the class of anti-diabetic drugs (type 2 diabetes) they act by increasing insulin release from beta cells of pancreases.

Q17. Antithyroid drugs decrease the synthesis of thyroxine by -

• A) Decreasing the availability of amino acid
• B) Destroying the cell in thyroid gland
• C) Interfering with incorporation of iodide thyroglobulin
• D) All of these

Answer: (C) Interfering with incorporation of iodide thyroglobulin

Antithyroid drugs (carbimazole, methimazole, and propyl thiouracil) act by inhibiting iodination of thyroglobulin.

Q18. Which one of these is an anabolic steroid?

• A) Testosterone propionate
• B) Fluxymesterone
• C) Stanozolol
• D) None of the above

Answer: (C) Stanozolol

Stanozolol, danozol, nandrolone, metenolone etc. are anabolic steroids.

Q19. Hydrocortisone differ from cortisone in possessing -

• A) Basic nucleus
• B) Double bond
• C) Hydroxy group in place of keto group at C-11
• D) None of the above

Answer: (C) Hydroxy group in place of keto group at C-11

At the C-11 position cortisone has C>=O group and hydrocortisone has >-OH group

Q20. Sulphonamides act as antibacterial drug due to -

• A) Free amino group
• B) Sulphonamide group
• C) Benzene nucleus
• D) None of the above

Answer: (A) Free amino group

The free amino group in sulphonamides is responsible for their abtibacterial action.

Q21. The structure of penicillin consists of

• A) Thiozolidine
• B) β -lactam
• C) Thiazolidine and β -lactam ring
• D) None of the above

Answer: (C) Thiazolidine and β -lactam ring

Penicillin consists of thiazolidine and β - lactam ring.

Q22. Which one if these antibiotics is effective in the treatment of intestinal amoebiasis?

• A) Streptomycin
• B) Paromomycin
• C) Ampicillin
• D) Chloramphenicol

Answer: (B) Paromomycin

Paromomycin is an aminoglycosides antibiotic, used to treat intestinal amoebiasis infections.

Q23. Vermox is a common brand for -

• A) Thiabendazole
• B) Piperazine
• C) Mebendazole
• D) Metronidazole

Answer: (C) Mebendazole

Vermox is the brand name for mebendazole which is anti-worm (anthelmintic) drug.

Q24. Which one of these drugs is used as an opthalmic diagnostic agent?

• A) Fluorescein sodium
• B) Congo red
• C) Methelene blue
• D) Indigo carmine

Answer: (A) Fluorescein sodium

Fluoresceine is orange red, non toxic and acidic dye of xanthene series. It is used as opthalmic diagnostic agents.

Q25. Evans blue is used to determine -

• A) Liver function
• B) kidney function
• C) Blood volume
• D) Ulceration in Eye cornea

Answer: (C) Blood volume

Evans blue is an azo dye which has very high affinity for serum albumin. Because of thus it is used to determine blood volume.

Q26. Which one of these vitamin is a naphthaquinone derivative?

• A) Vitamin C
• B) Vitamin A
• C) Vitamin K
• D) Vitamin D

Answer: (C) Vitamin K

Vitamin K is a group of structurally similar fat soluble vitamins having naphthaquinone ring (vitamin K1 and K2)

Q27. Chemical structure of halothene is-

• A) CH₃-CHBrCl
• B) CF₃ -CHCl-O-CHF₂
• C) C₃H₇ - O- CH₃
• D) CHF.Cl-CF₂-OCHF₂

Answer: (A) CH₃-CHBrCl

Halothane (Fluothane) is an inhalant general anesthatic.chemically it is 2-bromo-2-chloro-1,1,1-trifluoroethane.

Q28. The number of nitrogen atom in benzimidazole is :

• A) 2 in the same ring
• B) 3 in the same ring
• C) 1 in the five membered ring
• D) 2 in the different ring

Answer: (A) 2 in the same ring

2 nitogen atoms are present in one ring (same ring) of benzimidazole.

Q29. which one of these antineoplastic (anticancer) drugs contains platinum?

• A) Nitrogen mustard
• B) Busulphan
• C) Cisplatin
• D) Daunorubicin

Answer: (C) Cisplatin

Cisplatin is diamino-dichloro-platinum, anticancer drug. Now also include carbaplatin, oxaloplatin.

Q30. The organophosphate poisoning is treated by

• A) Neostigmine
• B) Physostigmine
• C) Pralidoxime
• D) Pyridostigmine

Answer: (C) Pralidoxime

Pralidoxime is used to treat the poisoning caused by organophosphate and ACH inhibitors.