Q1. Suganril is common brand name for:

• A) Phenylbutazone
• B) Piroxican
• C) Benorylate
• D) Indomethacin

Answer: (B) Piroxican

Piroxicam is used to relieve the symptoms of rheumatoid and osteoarthritis.

Q2. Which one of these is μ-opioid agonist?

• A) Pethidine
• B) Codeine
• C) Nalorphine
• D) None of these

Answer: (A) Pethidine

Pethidine is a phenyl piperidine that is also a strong agonist of μ-opioid receptor.

Q3. Levodopa is amino acid precursor of - 

• A) Adrenaline
• B) Dopamine
• C) Norepinephrine
• D) All of these

Answer: (D) All of these

levo dopa is the amino acid precursor for dopamine and also for adrenaline and noradrenaline.

Q4. The most potent CNS stimulant among xanthine bases are-

• A) Theophylline
• B) Caffeine
• C) Theobromine
• D) All of these

Answer: (B) Caffeine

Caffeine is the most potent CNS stimulant.

Q5. Chlorpromazine is useful in the treatment of -

• A) Mental depression
• B) Schizophrenia
• C) Parkinsonism
• D) None of the above

Answer: (B) Schizophrenia

Chlorpromazine (CPZ) is a dopamine antagonist of the typical antipsychotic class of medications possessing additional anti-adrenergic, anti-serotonergic, anti-cholinergic, and anti-histaminergic properties used to treat schizophrenia.

Q6. Amlodepine Lowers blood pressure by-

• A) Inhibition of calcium influx
• B) Inhibition of angiotensin converting enzyme (ACE)
• C) Blocking norepinephrine reuptake
• D) All of the above

Answer: (A) Inhibition of calcium influx

Amlodepine is a long acting dihydropyridine type calcium channel blocker.

Q7. Cholestyramine is useful in the treatment of -

• A) Arrhythmia
• B) Hypertension
• C) Hyper lipoproteinemia
• D) Angina pectoris

Answer: (C) Hyper lipoproteinemia

Cholestyramine is a bile acid sequestrant.

Q8. Clofibrate mainly Lowers the -

• A) LDL
• B) VLDL
• C) HDL
• D) Chylomicrons

Answer: (B) VLDL

Clofibrate is used for controlling cholesterol and triglycerides levels. It changes VLDL to LDL.

Q9. Lovastatin is useful in -

• A) High blood pressure
• B) Arrhythmia
• C) Hyper lipoproteinemia
• D) Angina pectoris

Answer: (C) Hyper lipoproteinemia

Lovastatin is a naturally occurring Drug in food, which controls blood cholesterol level. 

Q10. Oral anticoagulants act by antagonising the actions of -

• A) Calcium ion
• B) Prothrombin
• C) Vitamin K
• D) Fibrinogen

Answer: (C) Vitamin K

vitamin K is a fat soluble vitamin and is required for post translational modification.

Q11. Glucocorticoid are used in the treatment of :

• A) Inflammation
• B) Inflammation and allergy
• C) Skin infections
• D) Allergy

Answer: (B) Inflammation and allergy

 Glucocorticoids are the part of the feedback mechanism in the immune system that turns immune activity (inflammation).

Q12. The sulphonamides are :

• A) Bactericidal in nature
• B) Bacteriostatic in nature
• C) Bactericidal only at high dose
• D) None of the above

Answer: (B) Bacteriostatic in nature

A Sulphonamide displaces bilirubin. It is competitive inhibitor of enzyme DHPS, cause inhibition of folate synthesis and cause bacteriostatic action.

Q13. Tetracycline act by -

• A) Inhibition of protein synthesis
• B) Interfering in cell wall synthesis
• C) Altering the permeability of cell membrane of organism
• D) All of the above

Answer: (A) Inhibition of protein synthesis

Tetracycline is a broad spectrum antibiotic which reduces the growth of bacteria by inhibiting the protein synthesis. it binds with the 30s subunit of microbial ribosomes, to inhibit protein synthesis.

Q14. Nystatin is principally effective in:

• A) Candidia albicans
• B) Blastomyces
• C) Cryptococcus histoplasma
• D) All of the above

Answer: (A) Candidia albicans

Nystatin is a polyene antifungal medication derived from streptomyces noursei.

Q15. Pyridoxine is administered with isoniazid to minimise the:

• A) Hepatotoxicity
• B) Neurotoxicity
• C) Nephrotoxicity
• D) Allergic reaction

Answer: (C) Nephrotoxicity

Pyridoxine is also called vitamin B6, assist in the balancing of sodium and potassium as well as promoting RBC.

Q16. Which one of these combination is used in Chloroquine resistance malaria?

• A) Trimethoprim + pyrimethamine
• B) Pyrimethamine + sulphadoxine
• C) Mefloquine + Primaquine
• D) None of the above

Answer: (B) Pyrimethamine + sulphadoxine

Sulphadoxine + Pyrimethamine (Fansidar) is a combination antimalarial containing the sulphonamide antibiotic sulphadoxine and the anti-protozoal pyrimethamine.

Q17. Which one of the enzyme is used in the treatment of cancer?

• A) L- asparginase
• B) Phosphodiesterase
• C) Xanthine Oxidase
• D) None of the above

Answer: (A) L- asparginase

L- asparginase catalyzes the hydrolysis of asparagines to aspartic acid.

Q18. Eserine acts by -

• A) Receptor mechanism
• B) Acting on cell membrane
• C) Drug-enzyme interactions
• D) None of the above

Answer: (C) Drug-enzyme interactions

Eserine is another term for physostigmine is a highly toxic parasympathomimetic alkaloid.

Q19. Desferrioxamine is a :

• A) Chelating agent
• B) Antimetabolite
• C) Enzyme inhibitor
• D) None of the above

Answer: (A) Chelating agent

Desferrioxamine is a bacterial siderophore produced by the actinobateria, Streptomyces pilosos.

Q20. Sodium valproate prevent the epileptic seizure by -

• A) Depressing the CNS
• B) Preventing influx of sodium
• C) Preventing influx of calcium
• D) None of the above

Answer: (B) Preventing influx of sodium

Sodium valproate used in epilepsy, Anorexia, and bipolar disorder.

Q21. Which one of these is used with hyoscine to induce Twilight sleep?

• A) Pentazocine
• B) Pethidine
• C) Diphenhydramine
• D) None of the above

Answer: (B) Pethidine

Hyoscine is also known as levo-duboisine, tropane alkaloid.

Q22. Ergot preparations are useful in migraine due to its-

• A) Oxytocic action
• B) Vasoconstriction action
• C) α -receptors blocking action
• D) None of the above

Answer: (B) Vasoconstriction action

Q23. Which one of these is a major tranquilizer?

• A) Phenelzine
• B) Promethazine
• C) Trifluoperazine
• D) Hydroxyzine

Answer: (C) Trifluoperazine

trifluoperazine is a drug from phenothiazine chemical class is atypical antipsychotic drug.

Q24. Which one is a cholinomimetic agent?

• A) Atropine
• B) Salbutamol
• C) Tolbutamide
• D) Acetylcholine

Answer: (D) Acetylcholine

Acetylcholine mimics the action of the cholinergic system.

Q25. Testosterone is not orally active because?

• A) React with acid
• B) Degradation
• C) Reduction
• D) Rapid oxidation of 17-hydroxy group to ketones

Answer: (D) Rapid oxidation of 17-hydroxy group to ketones

Testosterone is an androgenic steroid hormone, responsible for male characteristics.

Q26. Which one of the following drug shows antiplatelet activity?

• A) Verapamil
• B) Nifedipine
• C) Warferin
• D) Dipyridamole

Answer: (D) Dipyridamole

Dipyridamole inhibits Thrombus formation.

Q27. Nociceptors are associated with:

• A) Chemical
• B) Pain
• C) Temperature
• D) Pressure

Answer: (B) Pain

A Nociceptor is a receptor of a sensory neuron (nerve cell) that responds to potentially damaging stimuli by sending signals to the spinal cord and brain. This process called nociception usually causes the perception of pain.

Q28. Drug that shows selective antagonistic selective H1 antagonistic action?

• A) Chlorpheniramine
• B) Cimetidine
• C) Ranitidine
• D) Thioperamide

Answer: (A) Chlorpheniramine

Chlorpheniramine is a first-generation alkylamine and anti-histamine for H1.
Cimetidine and ranitidine are H2 antagonists and inhibit stomach acid production.
Thioperamide is a selective H3 antagonist, and also capable of crossing the Blood-brain barrier.

Q29. Which one is the alkylating anticancer drug?

• A) Fluorouracil
• B) Vincristine
• C) Thiotepa
• D) Doxorubicin

Answer: (C) Thiotepa

Thiotepa is an organophosphorus compound, is an alkylating anticancer drug.

Q30. Which one is a HMGC A reductase inhibitor?

• A) Rhabdomylosis
• B) Nausea
• C) Vomiting
• D) Rise in serum transaminase

Answer: (A) Rhabdomylosis

Rhabdomyolysis is a condition in which damaged skeletal muscle tissue breaks down rapidly.