1
The amino acids required for the synthesis of purines and pyrimidines are
Glutamine and aspartate
2
The enzyme xanthine oxidase is inhibited by
Allopurinol
3
Tophi are mostly made up of
Sodium urate
4
Hypouricemia is due to the deficiency of the enzyme
Xanthine oxidase
5
The disorder in which the patients have an irresistible urge to bite their fingers and lips is
Lesch-Nyhan syndrome
6
The cofactor required by the enzyme ribonucleotide reductase is
Thioredoxin
7
The ‘parent’ nucleotide synthesized in the biosynthesis of purines is
Inosine monophosphate
8
Xanthine oxidase converts allopurinol to
Alloxanthine
9
The amino acid that contributes to the synthesis of more than half of the pyrimidine ring
Aspartate
10
The regulatory enzyme in the pyrimidine biosynthesis in animals is
Carbamoyl phosphate synthetase II
11
Name the enzyme associated with hyperuricemia
PRPP synthetase, HGPRT , Glucose 6-phosphatase
12
An enzyme of purine metabolism associated with immunodeficiency disease
Adenosine deaminase
13
Orotic aciduria can be treated by a diet rich in
Uridine
14
The end product of purine metabolism in humans is
Uric acid
15
The nitrogen atoms in the purine ring are obtained from
Glycine , Glutamine , Aspartate