Antihistamines that focus on the histamine H1-receptor are wont to treat allergies within the nose (e.g., itching, runny nose, and sneezing). additionally , they'll be wont to treat insomnia, kinetosis , or vertigo caused by problems with the internal ear.
H2-antihistamines bind to histamine H2 receptors within the upper alimentary canal , primarily within the stomach.
Antihistamines that focus on the histamine H2-receptor are wont to treat gastric acid conditions (e.g., peptic ulcers and acid reflux). Histamine receptors exhibit constitutive activity, so antihistamines can function as either a neutral receptor antagonist or an inverse agonist at histamine receptors. Only a couple of currently marketed H1-antihistamines are known to function as inverse agonists.
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